Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.

Infrequent zoledronate therapy prevents bone loss in older women

23 Mar 2020

Infrequent administration of zoledronate 5 mg at a 5.5-year interval has been shown to inhibit bone loss over 11 years, according to a study.

The investigators analysed the effect of very infrequent zoledronate therapy on bone mineral density (BMD) and markers of bone turnover at an academic research centre. Fifty older women with osteopaenia were randomly assigned to receive either a single dose of 5 mg zoledronate or placebo. Of the randomized participants, 33 entered a 5-year open-label extension study.

BMD and bone turnover were then measured each year for nearly 11 years, which generated data in women who received 5 mg of zoledronate at 0 and 5.5 years (ZZ, n=16) or placebo at baseline and 5 mg of zoledronate at 5.5 years (PZ, n=17).

BMD remained stable among women in the ZZ group but increased among those in the PZ group after redosing.

Corresponding changes from baseline BMD in the ZZ and PZ groups at 11 years were 3.8 percent (95 percent confidence interval [CI], 1.1–6.5) and 2.9 percent (95 percent CI, 0.3–5.5) at the lumbar spine (p=0.61), 0.9 percent (95 percent CI, –1.7 to 3.5) and –2.8 percent (95 percent CI, –5.3 to –0.3) at the total hip (p=0.006), and 0.4 percent (95 percent CI, –0.8 to 1.6) and –0.4 percent (95 percent CI, –1.3 to 0.5) at the total body (p=0.14).

Comparable bone turnover markers were observed in both groups throughout the 5 years after redosing.

“Clinical trials to investigate whether very infrequent treatment with zoledronate reduces fracture risk are justified,” the investigators said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.