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Pearl Toh, 03 Nov 2017
Increasing daily water intake by 1.5 L can half the risk of recurrent acute uncomplicated cystitis (rAUC) in women, suggests a study presented at the recent Infectious Disease Week (IDWeek) in San Diego, California, US.
24 Dec 2015
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Inflammatory response involved in human anaplasmosis pathophysiology

27 Sep 2017
The ticks that transmit Lyme disease can occasionally transmit other tickborne diseases as well.

Proinflammatory responses and immune dysfunction may play a role in the pathophysiology and severity of human anaplasmosis (HA), reveals a recent study.

The study included 80 HA patients (mean age 54.2±20.1 years; 62.5 percent male) and 1,000 healthy controls (mean age 64.3±11.3 years; 43.9 percent male). Concentrations of cytokines were measured in serum samples collected from the participants.

Levels of interferon gamma (IFN-γ; 5.00 vs 0.571 pg/mL; p<0.0001), interleukin (IL)-10 (3.70 vs 1.055 pg/mL; p<0.0001), IL-12p70 (1.79 vs 0.297 pg/mL; p<0.0001), IL-1β (0.55 vs 0.101 pg/mL; p<0.0001), IL-8 (3.67 vs 1.707 pg/mL; p<0.0001), tumour necrosis factor-α (TNF-α; 2.89 vs 1.585 pg/mL; p<0.0001) and IL-6 (2.34 vs 0.849 pg/mL; p<0.0001) were significantly higher in HA patients than in controls.

Vomiting and diarrhoea were significantly associated with elevated levels of IL-13 and IL-5 (p≤0.023 for both), while thrombocytopoenia was correlated with higher levels of IL-10, IL-1β, IL-8, IL-6 and IFN-γ (p≤0.031 for all).

IFN-γ, IL-12p70 and Il-2 were all significantly elevated in patients who were in the earliest stages of the disease and who were ill for at most 4 days (p≤0.048 for all). In contrast, those who were hospitalized had significantly higher concentrations of IL-19 and TNF-α (p≤0.036).

HA patients with morulae on blood smears also had significantly higher IL-1β, IL-6 and IL-10 concentrations in the serum samples (p≤0.03). On the other hand, there were no significant differences in the serum cytokine levels between sexes or among age groups. 

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Most Read Articles
Pearl Toh, 03 Nov 2017
Increasing daily water intake by 1.5 L can half the risk of recurrent acute uncomplicated cystitis (rAUC) in women, suggests a study presented at the recent Infectious Disease Week (IDWeek) in San Diego, California, US.
24 Dec 2015
Imipenem-cilastatin exhibited better efficacy than piperacillin-tazobactam as empiric antibiotic for febrile neutropaenia in haematopoietic stem cell transplantation (HSCT) recipients, based on a study.