Most Read Articles
Pearl Toh, 10 Oct 2019
Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
4 days ago
Eating alone may help in weight management as findings of a recent study suggest that eating with friends lead to higher food intake.
Tristan Manalac, 3 days ago
A digital-first approach, iConnect, allows patients to have greater access to services and guidance and enables healthcare providers to deliver much better postdischarge care, according to Lim Cher Wee, chief operating officer of the Ministry of Health, Office for Healthcare Transformation of Singapore, in his presentation at the recently concluded AsiaPac19 Conference & Exhibition of the Healthcare Information and Management Systems Society (HIMSS 2019).
Jairia Dela Cruz, 3 days ago
Toileting behaviours such as convenience and delayed voiding, straining to void, and position preference are strongly associated with overactive bladder (OAB) symptoms in women, according to a study.

Inflammatory eruptions tied to immune checkpoint inhibitors

11 Apr 2019
Near-infrared photoimmunotherapy, hypoxia-activated prodrugs and proton beam therapy may hail the future of cancer treatments

Immune checkpoint inhibitor therapy may lead to various inflammatory reactions with differing degrees of severity, suggests a recent study. Most rashes respond to topical treatment, but immunotherapy is often interrupted by immunobullous and exfoliative presentations.

Ninety-eight patients (47 women) who received immune checkpoint inhibitors developed 103 inflammatory eruptions, with a range of mean latency of 0.2–17.7 months.

Immunotherapy was interrupted in a few patients (25/103; 24.3 percent), most of which involved immunobullous (7/8; 87.5 percent), lichenoid (8/26; 30.8 percent), maculopapular (6/18; 33.3 percent) and Stevens-Johnsons syndrome–like reactions (2/2; 100 percent).

Of the 16 patients who had their immunotherapy interrupted, only three (18.8 percent) had a grade 2 or 3 flare on rechallenge. Most reactions (93/103; 90.3 percent) responded to dermatologic therapy or immunotherapy interruption.

“Increased awareness and early recognition could reduce the need for unnecessary immunotherapy interruption,” the authors said.

This study aimed to analyse the different rashes linked to immunotherapy referred to an institution’s oncodermatology clinic and inpatient consultative service, as well as to assess their therapeutic response and impact on immunotherapy.

The authors conducted a retrospective review of medical records of patients during 2016–2018 at Yale-New Haven Hospital for eruptions that developed during immunotherapy. The study was limited by its retrospective design from a single tertiary care centre.

“There is increasing recognition of distinct inflammatory eruptions associated with checkpoint inhibitors,” the authors noted. “A better understanding of their severity, therapeutic response, and impact on cancer treatment is needed.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 10 Oct 2019
Adding a LAMA* to the double combination therapy of ICS** plus LABA*** in a single inhaler improves lung function and reduces exacerbations in patients whose asthma is inadequately controlled with the combination treatment, according to the TRIMARAN and TRIGGER# studies presented at ERS 2019.
4 days ago
Eating alone may help in weight management as findings of a recent study suggest that eating with friends lead to higher food intake.
Tristan Manalac, 3 days ago
A digital-first approach, iConnect, allows patients to have greater access to services and guidance and enables healthcare providers to deliver much better postdischarge care, according to Lim Cher Wee, chief operating officer of the Ministry of Health, Office for Healthcare Transformation of Singapore, in his presentation at the recently concluded AsiaPac19 Conference & Exhibition of the Healthcare Information and Management Systems Society (HIMSS 2019).
Jairia Dela Cruz, 3 days ago
Toileting behaviours such as convenience and delayed voiding, straining to void, and position preference are strongly associated with overactive bladder (OAB) symptoms in women, according to a study.