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Inflammatory dietary pattern does not increase risk for incident psoriasis, PsA, atopic dermatitis

16 Jun 2019

Pro-inflammatory dietary patterns are not associated with the risk of incident psoriasis, psoriatic arthritis (PsA) or atopic dermatitis (AD), a recent study has found.

A total of 85,185 participants were included in the psoriasis analysis and 63,443 in the AD analysis. Recorded cases of psoriasis, PsA and AD were 1,432, 262 and 403, respectively.

Multivariable models showed no association between pro-inflammatory dietary patterns and risk for outcomes (p-trend>0.05 for all). Hazard ratios comparing the highest to the lowest Empirical Dietary Inflammatory Pattern (EDIP) quintile were 0.99 (95 percent CI, 0.83–1.18) for psoriasis, 1.22 (0.81–1.83) for PsA and 0.96 (0.69–1.34) for AD.

“Our findings do not support dietary inflammatory potential as a risk factor for psoriasis, PsA or AD,” the authors said.

A separate study found no link between EDIP and rheumatoid arthritis (RA) among women >55 years (p=0.03), while an inflammatory dietary pattern was found to correlate with increased seropositive RA risk with onset ≤55 years old, which might be partially mediated through body mass index. [Clin Rheumatol 2019;38:243-250]

In the current analysis, cohort studies among women in the Nurses’ Health Study II were conducted to assess the association between pro-inflammatory dietary patterns and incident psoriasis, PsA and AD. The EDIP score was calculated at baseline and every 4 years. Validated self-reports were utilized to assess incident psoriasis, PsA and AD.

Multivariable-adjusted Cox proportional hazards models were generated to calculate HRs and 95 percent CIs for the relationship between EDIP quintiles and risk for psoriasis, PsA and AD. The study, however, was limited by use of recall and self-report.

“Diet is a modulator of inflammation that might impact inflammatory skin diseases,” the authors said.

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