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Inferior vena cava filters reduce mortality in elderly patients with pulmonary embolism, cancer

16 Apr 2018

Elderly patients with pulmonary embolism and cancer seem to benefit from inferior vena cava filters, which reduce in-hospital and 3-month all-cause mortality, according to a study.

In-hospital all-cause mortality was lower among patients aged >60 years with vena cava filters than those without filters (7.4 percent vs 11.2 percent; relative risk [RR], 0.67; p<0.0001). Patients aged >60 years who received vena cava filters also had a lower all-cause mortality within 3 months compared with those who did not receive a filter (15.2 percent vs 17.4 percent; RR, 0.86; p<0.0001).

“Further investigation is needed, particularly in younger patients,” the investigators said.

Analysis was carried out using administrative data from the Premier Healthcare Database, 2010–2014, in patients hospitalized with pulmonary embolism and solid malignant tumours. The International Classification of Disease, Ninth Revision, Clinical Modification codes were used to identify patients.

“Administrative data have shown a lower mortality in hospitalized patients with pulmonary embolism and cancer who receive a vena cava filter. In the absence of a randomized controlled trial of vena cava filters in such patients, further investigation is necessary,” the investigators noted.

In a subgroup analysis of the same study, results showed that the additional use of an inferior vena cava filter reduced in-hospital mortality among stable patients with acute pulmonary embolism receiving thrombolytic therapy. [Am J Med 2018;131:97-99]

These findings support those of a 2012 study, which concluded that inferior vena cava filter is a safe and effective method for pulmonary thromboembolism prophylaxis, especially for patients with high bleeding risk and who cannot be anticoagulated. [Turk Neurosurg 2012;22:269-273]

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Most Read Articles
18 Apr 2018
Higher intake levels of coffee appear to be associated with reduced risk of developing chronic kidney disease, according to data from the Atherosclerosis Risk in Communities Study.
Jairia Dela Cruz, 5 days ago
Infants delivered via caesarean section may be at increased risk of developing acute lymphoblastic leukaemia, according to a US study. Altered microbiota colonization is a possible explanation for this risk, although clear biological mechanisms have yet to be established.
4 days ago
Treatment with danegaptide does not improve myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention, according to the results of a phase II study.
4 days ago
Men with high levels of exposure to diesel exhaust are at greater risk of developing amyotrophic lateral sclerosis (AML), as shown in a recent study. This is not true for women.