Most Read Articles
6 days ago
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
04 Dec 2017
Later timing of puberty seems to correlate with lower areal bone mineral density in children and may affect the eventual risk of osteoporosis, a recent study suggests.
Jairia Dela Cruz, 6 days ago
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
3 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.

Infections, respiratory tract disease linked to elevated risk of IIM

22 Sep 2017

Individuals with a history of infection or respiratory tract disease are at greater risk of developing idiopathic inflammatory myopathy (IIM), suggesting that the triggering of the immune system may occur outside the skeletal muscle, according to a case–control study.

Using data from Swedish nationwide registers, researchers identified 957 patients with IIM (mean age 59 years; 57 percent female). Each patient was matched with non-IIM controls by age, sex and place of residence (n=9,476). Data on outpatient visits and hospitalizations for infection or respiratory disease prior to IIM diagnosis were also drawn from the registers.

Conditional logistic regression models were applied to test the association between infection or respiratory tract disease and future risk of developing IIM. Sensitivity analyses were also performed by changing the exposure definition, controlling for previous healthcare consumption and excluding individuals with connective tissue disease, IIM lung phenotype or IIM-associated cancer.

Results revealed that preceding infections occurred more frequently in the IIM group than in the control group (13 vs 9 percent) and were associated with an increased risk of IIM (odds ratio [OR], 1.5; 95 percent CI, 1.2 to 1.9). Specifically, gastrointestinal and respiratory tract infections were linked to a heightened IIM risk, whereas cutaneous infections were not.

Likewise, preceding respiratory tract disease was more common in the IIM group than in the control group (10 vs 4 percent), increasing the risk of developing IIM by more than twofold (OR, 2.3; 1.8 to 3.0). Both upper and lower respiratory tract diseases were associated with an increased risk of IIM.

Researchers noted that variations in exposure and outcome definitions had no significant effect on the results.

The present data suggest that external triggers of immunomodulation could be part of the aetiology of IIM, with the events possibly presenting years before the clinical manifestations of IIM become evident, researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
6 days ago
Survival in age-related macular degeneration (AMD) may be lower in patients with late disease, bilateral cataract surgery and poor visual acuity, according to data from the Age-Related Eye Disease Study 2. Moreover, oral supplementation with omega-3 fatty acids, lutein plus zeaxanthin, zinc or beta-carotene does not significantly affect mortality.
04 Dec 2017
Later timing of puberty seems to correlate with lower areal bone mineral density in children and may affect the eventual risk of osteoporosis, a recent study suggests.
Jairia Dela Cruz, 6 days ago
Discontinuation of aspirin may have detrimental consequences for long-term users, with a recent study reporting that cessation of use in the absence of major surgery or bleeding increases the risk of cardiovascular events.
3 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.