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Individualized approach may effectively stave off Alzheimer’s

10 Nov 2019

Individualized interventions involving multidomain techniques appear to be effective for slowing cognitive decline among persons at risk for Alzheimer’s disease (AD) dementia, a recent study has found.

A total of 174 participants (aged 25–86 years) were enrolled and assigned to tailored interventions. Those with normal cognition, subjective cognitive decline or preclinical AD were assigned to a prevention intervention, while patients with mild cognitive impairment or mild AD were given the early treatment intervention.

The 18-month change values in the modified Alzheimer’s Prevention Cognitive Composite (mAPCC) were 4.6 and 4.5 points in the high- and low-compliance subgroups of the prevention intervention arm, respectively. Both were statistically significant relative to baseline scores (p<0.0001 and p=0.0002, respectively), without no meaningful difference between subgroups.

In those who were assigned to early treatment, high compliance led to a 4.8-point increase in mAPCC scores, though this failed to reach statistical significance (p=0.1073). In contrast, participants with low compliance experienced significant worsening by 6.0 points (p=0.0148). The between-subgroup difference was also significant (p=0.0007).

Compared with historical controls, the prevention intervention led to a significantly greater improvement in mAPCC scores for both high- and low-compliance subgroups. In comparison, the early treatment was only significantly better than historical controls for patients with good compliance.

“To our knowledge, this is the first empirical trial in a clinical setting indicating that individualized AD risk factor management may improve cognitive function which may be related to AD pathology,” said researchers.

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