Most Read Articles
Natalia Reoutova, 07 Jan 2020

A prospective cohort study of mothers taking antiepileptic drugs (AEDs) and their breastfed infants has found substantially lower AED concentrations in infant vs maternal blood, with nearly half of all obtained AED concentrations in nursing infants being less than the lower limit of quantification (LLoQ).

Natalia Reoutova, 07 Jan 2020

A large prospective Chinese cohort study has found long sleep duration (≥9 hours/night) and long mid-day napping (>90 minutes) to be significantly associated with a higher risk of ischaemic stroke.

13 Aug 2017
Patients with Down syndrome (DS) have lower blood concentrations of zinc, selenium and calcium, and higher blood cell levels of copper and zinc, according to a systematic review.

Individualized approach may effectively stave off Alzheimer’s

10 Nov 2019

Individualized interventions involving multidomain techniques appear to be effective for slowing cognitive decline among persons at risk for Alzheimer’s disease (AD) dementia, a recent study has found.

A total of 174 participants (aged 25–86 years) were enrolled and assigned to tailored interventions. Those with normal cognition, subjective cognitive decline or preclinical AD were assigned to a prevention intervention, while patients with mild cognitive impairment or mild AD were given the early treatment intervention.

The 18-month change values in the modified Alzheimer’s Prevention Cognitive Composite (mAPCC) were 4.6 and 4.5 points in the high- and low-compliance subgroups of the prevention intervention arm, respectively. Both were statistically significant relative to baseline scores (p<0.0001 and p=0.0002, respectively), without no meaningful difference between subgroups.

In those who were assigned to early treatment, high compliance led to a 4.8-point increase in mAPCC scores, though this failed to reach statistical significance (p=0.1073). In contrast, participants with low compliance experienced significant worsening by 6.0 points (p=0.0148). The between-subgroup difference was also significant (p=0.0007).

Compared with historical controls, the prevention intervention led to a significantly greater improvement in mAPCC scores for both high- and low-compliance subgroups. In comparison, the early treatment was only significantly better than historical controls for patients with good compliance.

“To our knowledge, this is the first empirical trial in a clinical setting indicating that individualized AD risk factor management may improve cognitive function which may be related to AD pathology,” said researchers.

Editor's Recommendations
Most Read Articles
Natalia Reoutova, 07 Jan 2020

A prospective cohort study of mothers taking antiepileptic drugs (AEDs) and their breastfed infants has found substantially lower AED concentrations in infant vs maternal blood, with nearly half of all obtained AED concentrations in nursing infants being less than the lower limit of quantification (LLoQ).

Natalia Reoutova, 07 Jan 2020

A large prospective Chinese cohort study has found long sleep duration (≥9 hours/night) and long mid-day napping (>90 minutes) to be significantly associated with a higher risk of ischaemic stroke.

13 Aug 2017
Patients with Down syndrome (DS) have lower blood concentrations of zinc, selenium and calcium, and higher blood cell levels of copper and zinc, according to a systematic review.