Increased serum uric acid a major risk factor for hypertension in prehypertensive patients
Prehypertensive patients with increased serum uric acid levels are at high risk of developing hypertension, according to a study.
Researchers retrospectively examined data from 3,584 Japanese adults (mean age 52.1 years; 58.06 percent male) who were found to be prehypertensive in 2004 and re-examined in 2009. They estimated the cumulative incidences of hypertension over 5 years and identified risk factors for developing hypertension.
Over 5 years, the cumulative incidence of hypertension in patients with prehypertension was 25.3 percent. The incidence rates did not significantly differ between women and men (24.4 vs 26.0 percent; p=0.28).
However, the cumulative incidence of hypertension in the group of individuals with abnormally high serum uric acid levels (n=726) was significantly higher than in the group of those without hyperuricaemia (n=2,858; 30.7 vs 24.0 percent; p<0.001).
Risk factors for developing hypertension from prehypertension included age (adjusted odds ratio [aOR], 1.023; p<0.001), female sex (aOR, 1.595; p<0.001), higher body mass index (aOR, 1.051; p<0.001), higher baseline systolic (aOR, 1.072; p<0.001) and diastolic blood pressure (aOR, 1.085; p<0.001), and higher serum uric acid (aOR, 1.149; p<0.001).
The present data suggest that serum uric acid may be an important modifiable risk factor in managing patients with prehypertension, researchers said. Additional research must be conducted to ascertain whether the treatments for hyperuricaemia in prehypertensive individuals are useful for preventing the development of hypertension.