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Pearl Toh, 13 Jan 2018
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Increased serum uric acid a major risk factor for hypertension in prehypertensive patients

27 Dec 2017

Prehypertensive patients with increased serum uric acid levels are at high risk of developing hypertension, according to a study.

Researchers retrospectively examined data from 3,584 Japanese adults (mean age 52.1 years; 58.06 percent male) who were found to be prehypertensive in 2004 and re-examined in 2009. They estimated the cumulative incidences of hypertension over 5 years and identified risk factors for developing hypertension.

Over 5 years, the cumulative incidence of hypertension in patients with prehypertension was 25.3 percent. The incidence rates did not significantly differ between women and men (24.4 vs 26.0 percent; p=0.28).

However, the cumulative incidence of hypertension in the group of individuals with abnormally high serum uric acid levels (n=726) was significantly higher than in the group of those without hyperuricaemia (n=2,858; 30.7 vs 24.0 percent; p<0.001).

Risk factors for developing hypertension from prehypertension included age (adjusted odds ratio [aOR], 1.023; p<0.001), female sex (aOR, 1.595; p<0.001), higher body mass index (aOR, 1.051; p<0.001), higher baseline systolic (aOR, 1.072; p<0.001) and diastolic blood pressure (aOR, 1.085; p<0.001), and higher serum uric acid (aOR, 1.149; p<0.001).

The present data suggest that serum uric acid may be an important modifiable risk factor in managing patients with prehypertension, researchers said. Additional research must be conducted to ascertain whether the treatments for hyperuricaemia in prehypertensive individuals are useful for preventing the development of hypertension.

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Most Read Articles
Pearl Toh, 13 Jan 2018
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 5 days ago
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
Yesterday
Rates of immunization particularly in a primary care setting can be improved by constant patient reminders and recall systems, a recent study has found.
Roshini Claire Anthony, 2 days ago

The combination of ceftazidime and avibactam proved noninferior to meropenem in adults with nosocomial pneumonia, positioning it as a potential treatment option for this condition, results from the phase III REPROVE* trial show. Nonetheless, the combination was associated with a higher number of safety events compared with meropenem.