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Increased plasma aldosterone concentrations up risk of atherosclerosis

18 Oct 2019

Higher values of plasma aldosterone concentration (PAC) show a robust association with some metabolic variables, including triglycerides, urinary albumin excretion (UAE), carotid intima-media thickness (cIMT), worse ankle-brachial index (ABI) and major prevalence of carotid plaques, a recent study has shown.

These variables, alongside high blood pressure values, strongly correlated with an increased risk of atherosclerosis and cardiovascular complications.

This study sought to examine the association between PAC and some surrogate markers of subclinical atherosclerosis, such as cIMT, ABI and biochemical parameters in patients with essential hypertension.

A total of 804 essential hypertensive patients (mean age, 50±14 years; 407 men) without cardiovascular complications were consecutively enrolled from January 2014 to December 2017 and were categorized into quartiles based on their PAC values.

The highest PAC quartile, compared with the first quartile, correlated with the highest levels of serum uric acid (5.3±1.3 vs 5.0±1.0 mg/dl; p=0.01), triglycerides (117.5±15.7 vs 106.8±10.5 mg/dl; p<0.05), 24-h UAE (38.8±7.6 mg/24 h; p<0.05), cIMT (0.87±0.22 vs 0.80±0.21 mm; p=0.001) and increased prevalence of carotid plaques (26 percent vs 16 percent; p<0.005).

In addition, patients with PAC >150 pg/ml had significantly lower ABI than those with PAC <150 pg/ml (1.01±0.09 vs 1.10±0.09; p<0.022). Moreover, PAC independently predicted the presence of carotid plaques and pathological ABI (<0.9) in essential hypertensive individuals.

“The adrenal mineralocorticoid system plays a key role in cardiovascular, metabolic and renal damage,” the authors noted.

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Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.