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Roshini Claire Anthony, 3 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

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Increased plasma aldosterone concentrations up risk of atherosclerosis

18 Oct 2019

Higher values of plasma aldosterone concentration (PAC) show a robust association with some metabolic variables, including triglycerides, urinary albumin excretion (UAE), carotid intima-media thickness (cIMT), worse ankle-brachial index (ABI) and major prevalence of carotid plaques, a recent study has shown.

These variables, alongside high blood pressure values, strongly correlated with an increased risk of atherosclerosis and cardiovascular complications.

This study sought to examine the association between PAC and some surrogate markers of subclinical atherosclerosis, such as cIMT, ABI and biochemical parameters in patients with essential hypertension.

A total of 804 essential hypertensive patients (mean age, 50±14 years; 407 men) without cardiovascular complications were consecutively enrolled from January 2014 to December 2017 and were categorized into quartiles based on their PAC values.

The highest PAC quartile, compared with the first quartile, correlated with the highest levels of serum uric acid (5.3±1.3 vs 5.0±1.0 mg/dl; p=0.01), triglycerides (117.5±15.7 vs 106.8±10.5 mg/dl; p<0.05), 24-h UAE (38.8±7.6 mg/24 h; p<0.05), cIMT (0.87±0.22 vs 0.80±0.21 mm; p=0.001) and increased prevalence of carotid plaques (26 percent vs 16 percent; p<0.005).

In addition, patients with PAC >150 pg/ml had significantly lower ABI than those with PAC <150 pg/ml (1.01±0.09 vs 1.10±0.09; p<0.022). Moreover, PAC independently predicted the presence of carotid plaques and pathological ABI (<0.9) in essential hypertensive individuals.

“The adrenal mineralocorticoid system plays a key role in cardiovascular, metabolic and renal damage,” the authors noted.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
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Brodalumab has exhibited long-term efficacy and consistent safety profile for more than 2 years in the treatment of patients with psoriasis, results of the phase III AMAGINE-2 trial show.
19 Jan 2020
Anaemia increases mortality risk in heart failure (HF) patients across the ejection fraction (EF) spectrum, a recent study has found. The effect appears to be stronger in preserved (HFpEF) and midrange (HFmrEF) than in reduced (HFrEF) EF disease.