Most Read Articles
3 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

Yesterday
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
3 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
Yesterday
The risk factors and outcomes associated with an increased risk of permanent pacing include atrial fibrillation (AF) ablation, multivalve surgery and New York Heart Association (NYHA) functional class III/IV, a recent study has found.

Increased faecal calprotectin signals worse disease activity in axial spondyloarthritis

06 Feb 2019

Gut inflammation, as indicated by elevated faecal calprotectin levels, may be a marker of more severe disease in patients with axial spondyloarthritis (axSpA), according to data from the SPARTAKUS cohort. Specifically, increased calprotectin levels are associated with worse disease activity and physical function.

Researchers analysed the association of faecal calprotectin levels and the presence of anti-Saccharomyces cerevisiae antibodies (ASCA) in serum with disease subtype and current status in consecutive patients with a clinical axSpA diagnosis, which was classified as nonradiographic (nr-axSpA; n=40) or ankylosing spondylitis (AS; n=90), and in healthy controls (n=35).

Faecal calprotectin levels were elevated (50 mg/kg) in 27 percent of nr-axSpA patients, 38 percent of AS patients and 6 percent of controls. Of note, the levels were significantly higher in AS vs nr-axSpA patients (geometric mean, 41 vs 24 mg/kg; p=0.037) and in each axSpA subtype vs controls.

Overall, axSpA patients with elevated vs normal F-calprotectin levels showed worse disease activity and physical function scores, with marked differences in the visual analogue scale for global health, Ankylosing Spondylitis Disease Activity Score using C-reactive protein, and the Bath AS Functional.

Meanwhile, ASCA titres and seropositivity (10 U/ml) were similar in the nr-axSpA (IgA/IgG-seropositivity: 8 percent and 26 percent, respectively) and AS (IgA/IgG-seropositivity: 7 percent and 28 percent, respectively) cohorts. Clinical outcome measures did not significantly differ between patients with elevated vs normal ASCA IgA or IgG.

Compared with controls, patients in both axSpA subtypes had significantly greater ASCA IgA, while those in the AS group had markedly increased ACSA IgG.

The present data are in line with previous observations of more pronounced sacroiliitis in patients with microscopic gut inflammation, thus providing further evidence of an important interplay between gastrointestinal and musculoskeletal manifestations of axSpA, as researchers pointed out.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
3 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

Yesterday
Susceptibility‐guided therapy is as effective as empiric modified bismuth quadruple therapy for the first-line treatment of Helicobacter pylori infection, with both yielding excellent eradication rates, as shown in a recent trial.
3 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
Yesterday
The risk factors and outcomes associated with an increased risk of permanent pacing include atrial fibrillation (AF) ablation, multivalve surgery and New York Heart Association (NYHA) functional class III/IV, a recent study has found.