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Increased exercise tied to lower mortality risk in adults with T2D

Elaine Soliven
15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

“Exercise improves insulin sensitivity, inhibits inflammatory cytokines, and reduces the risk of cardiovascular disease ... [However,] the effect of exercise capacity on all-cause mortality in people with diabetes has not been fully explored,” said Dr Yun-Ju Lai from the Division of Endocrinology and Metabolism, Department of Internal Medicine at Puli Branch of Taichung Veterans General Hospital in Nantou, Taiwan.

“[Therefore, our aim was] to investigate [the] association between exercise [capacity] and all-cause mortality in people with T2D,” she highlighted.

Using data from the National Health Interview Survey and the National Health Insurance research database from 2000–2016 in Taiwan, the researchers conducted a study involving 4,859 adults with T2D (mean age 59.5 years, 49.17 percent male). Participants were assessed and interviewed regarding their exercise capacity, such as how often they exercise in a week, what kind of exercise, and how long they exercise. Subjects were followed up until December 31, 2016. [EASD 2020, abstract 267]

A total of 996 death cases were reported during the entire study period.

After adjusting for potential confounders, individuals who engaged in a high amount of exercise (>800 kcal/week) had a 32 percent lower risk of all-cause mortality than those with no exercise habits (adjusted hazard ratio [HR], 0.68, 95 percent confidence interval [CI], 0.57–0.81; p<0.0001).

In addition, those who performed a moderate amount of exercise (0–800 kcal/week) achieved a 25 percent lower risk of all-cause mortality compared with those without exercise habits (adjusted HR, 0.75, 95 percent CI, 0.62–0.91; p<0.0041).

“Among people with T2D, those with increased exercise capacity had a significantly decreased risk of all-cause mortality,” Lai concluded, who suggested that “further studies should investigate the type and dose of exercise that is most helpful to promote health and prolong life expectancy.”

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Most Read Articles
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Elvira Manzano, 07 Oct 2020
Exendin-4 imaging targeting GLP-1* receptor (GLP-1R) ably detects residual, dysfunctional pancreatic beta cells in individuals with long-standing type 1 diabetes (T1D), according to a study presented at EASD 2020. This breakthrough brings research closer to the possibility of restoring insulin-producing cells depleted in T1D.
Elaine Soliven, 4 days ago
Ultra rapid lispro (URLi) was noninferior to lispro in reducing HbA1c levels in adults with type 1 diabetes (T1D), according to the PRONTO-Pump-2* study presented at EASD 2020.