Most Read Articles
01 Nov 2013

Joint stiffness is defined as discomfort after a period of inactivity. It is associated with reduced or loss of range of motion in a joint.

01 Aug 2016
Etoricoxib exhibits a central mode of action and enhances pain and function in patients with painful knew osteoarthritis (OA), as presented in a randomised, double-blind, placebo-controlled, two-way crossover, four-week treatment study.
Stephen Padilla, 25 Nov 2016
The addition of supervised physiotherapy to usual care does not provide clinically important improvement in the management of simple ankle sprains in a general population of patients seeking hospital-based acute care, according to results of a recent randomized controlled trial.
24 Jul 2017
The toxic side-effects of chemotherapy appear to be induced by cell-free chromatin (cfCh) fragments released from dying cells, triggering DNA damage, apoptosis and inflammation in healthy cells, thereby exaggerating or amplifying the toxic effects caused by the drugs themselves, according to a study.

In vitro fertilization may be effectively done in women with SLE, APS

17 May 2017

It is possible to safely and successfully perform in vitro fertilization (IVF) in women with systemic lupus erythematosus (SLE) or antiphospholipid syndrome (APS), suggests a recent study.

A retrospective study was conducted to describe women with SLE or APS who have had at least one IVF cycle. Researchers compiled and assessed data about complication and success rates for IVF.

A total of 37 women (median age 34 years; range, 26 to 46) with SLE (n=23, including eight with antiphospholipid antibodies), SLE with APS (n=4) or primary APS (n=10) underwent 97 IVF procedures (median number of IVF cycles, 2.6; range, 1 to 8). The infertility was female in origin in 43 percent of cases, male in 19 percent, mixed in 14 percent and unexplained in 24 percent.

There was no woman who had premature ovarian insufficiency due to cyclophosphamide. Patients were treated with hydroxychloroquine (72 percent), steroids (70 percent), azathioprine (3 percent), aspirin (92 percent) or low molecular weight heparin (62 percent).

There were 27 (28 percent) pregnancies, 23 live births among 26 neonates (three twin pregnancies), two miscarriages, and two terminations for trisomy 13 and 21. During follow-up, six spontaneous pregnancies occurred. A total of 26 women (70 percent) delivered at least one healthy child.

Complications happened in or after eight IVF cycles (8 percent): SLE flares in four (polyarthritis in three and lupus enteritis in one) and thromboembolic events in four others. One of the SLE flares was the initial sign of previously undetected SLE. In two other flares and two thrombosis, it was obvious that patients had poor treatment adherence.

There was no ovarian hyperstimulation reported, according to researchers.

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Most Read Articles
01 Nov 2013

Joint stiffness is defined as discomfort after a period of inactivity. It is associated with reduced or loss of range of motion in a joint.

01 Aug 2016
Etoricoxib exhibits a central mode of action and enhances pain and function in patients with painful knew osteoarthritis (OA), as presented in a randomised, double-blind, placebo-controlled, two-way crossover, four-week treatment study.
Stephen Padilla, 25 Nov 2016
The addition of supervised physiotherapy to usual care does not provide clinically important improvement in the management of simple ankle sprains in a general population of patients seeking hospital-based acute care, according to results of a recent randomized controlled trial.
24 Jul 2017
The toxic side-effects of chemotherapy appear to be induced by cell-free chromatin (cfCh) fragments released from dying cells, triggering DNA damage, apoptosis and inflammation in healthy cells, thereby exaggerating or amplifying the toxic effects caused by the drugs themselves, according to a study.