Most Read Articles
04 Oct 2020
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Roshini Claire Anthony, 3 days ago

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

09 Nov 2020
Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.
07 Aug 2020
Concomitant treatment with a nonsteroidal anti-inflammatory drug (NSAID) following myocardial infarction (MI) is associated with a higher risk of cardiovascular and bleeding events, a study has shown.

In-home just as good as in-clinic monitoring of warfarin therapy

08 Nov 2020

Among patients with mechanical heart valves receiving warfarin anticoagulation, in-home does not differ from in-clinic monitoring of international normalized ratio (INR) in terms of therapeutic range (TTR) and important clinical outcomes, according to real-world data.

The analysis included 383 patients (mean age, 61.5 years; 38.6 percent female), 145 (37.9 percent) of which were managed by in-home monitoring (case) and 238 (62.1 percent) were monitored in the clinic (control).

Position of mechanical heart valves was aortic in 77.8 percent of the population, mitral in 31.1 percent, tricuspid in 1 percent, pulmonic in 0.2 percent, and multiple in 9.7 percent. The target INR was 2.5 for 199 patients (52.0 percent) and 3.0 for 184 (48.0 percent).

Over a median follow-up of 3.1 years, mean TTR did not significantly differ between in-home and in-clinic monitoring (66.6 percent vs 67.2 percent, respectively; p=0.76). Furthermore, the two groups had similar rates of survival to major bleeding (5.7 percent vs 6.7 percent per person-year; p=0.66) or thrombotic complications (2.3 percent vs 1.8 percent; p=0.56).

Notably, in-home monitoring was associated with a lower risk of all-cause death (hazard ratio, 0.40, 95 percent confidence interval, 0.19–0.83; p=0.01) on univariate analysis. However, this association disappeared in an analysis adjusted for age and baseline left ventricular ejection fraction.

Based on the present data, patient self-testing, which is cost-effective on a population basis compared with in-clinic monitoring, should be considered for all patients with mechanical heart valves.

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Most Read Articles
04 Oct 2020
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Roshini Claire Anthony, 3 days ago

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

09 Nov 2020
Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.
07 Aug 2020
Concomitant treatment with a nonsteroidal anti-inflammatory drug (NSAID) following myocardial infarction (MI) is associated with a higher risk of cardiovascular and bleeding events, a study has shown.