Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

16 Aug 2014

New drug applications approved by US FDA as of 15-30 Aug which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.

Improving fitness lowers risk of diabetes in statin-treated dyslipidaemic patients

03 Oct 2017

In statin-treated patients with dyslipidaemia, the risk of diabetes is inversely and independently associated with cardiorespiratory fitness, according to a study. Furthermore, only those with relatively low cardiorespiratory fitness have an elevated diabetes risk.

Researchers identified dyslipidaemic patients with a normal exercise test performed during 1986 and 2014 at the Veterans Affairs Medical Centers in the United States to examine the association between cardiorespiratory fitness and diabetes incidence. A total of 4,092 statin-treated patients (mean age 58.8 years; 2,701 Blacks) were included. None had evidence of type 2 diabetes (T2D) prior to statin therapy.

Four fitness categories were created based on age and peak metabolic equivalents achieved: Least-fit (n=954), Low-fit (n=1,201), Moderate-fit (n=1,242) and High-fit (n=695). Serving as controls were nonstatin-treated individuals (n=3,001; mean age 57.2 years) with no evidence of T2D prior to the exercise test.

Statin-treated patients had a 24-percent higher incidence of diabetes than nonstatin-treated participants (p<0.001). A total of 1,075 patients (26.3 percent) in the statin-treated cohort developed diabetes (average annual incidence rate, 30.6 events per 1,000 person-years).

With increasing fitness, the adjusted risk progressively decreased and was 34 percent lower for High-fit patients compared with the Least-fit (hazard ratio [HR], 0.66; 95 percent CI, 0.53 to 0.82; p<0.001) group. Compared with the nonstatin cohort, the risk of diabetes was elevated only in the Least-fit (HR, 1.50; 1.30 to 1.73; p<0.001) and Low-fit patients (HR, 1.22; 1.06 to 1.41; p=0.006).

“Improving fitness may modulate the potential diabetogenic effects of statins,” according to researchers.

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Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

16 Aug 2014

New drug applications approved by US FDA as of 15-30 Aug which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.