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Improving fitness lowers risk of diabetes in statin-treated dyslipidaemic patients

03 Oct 2017

In statin-treated patients with dyslipidaemia, the risk of diabetes is inversely and independently associated with cardiorespiratory fitness, according to a study. Furthermore, only those with relatively low cardiorespiratory fitness have an elevated diabetes risk.

Researchers identified dyslipidaemic patients with a normal exercise test performed during 1986 and 2014 at the Veterans Affairs Medical Centers in the United States to examine the association between cardiorespiratory fitness and diabetes incidence. A total of 4,092 statin-treated patients (mean age 58.8 years; 2,701 Blacks) were included. None had evidence of type 2 diabetes (T2D) prior to statin therapy.

Four fitness categories were created based on age and peak metabolic equivalents achieved: Least-fit (n=954), Low-fit (n=1,201), Moderate-fit (n=1,242) and High-fit (n=695). Serving as controls were nonstatin-treated individuals (n=3,001; mean age 57.2 years) with no evidence of T2D prior to the exercise test.

Statin-treated patients had a 24-percent higher incidence of diabetes than nonstatin-treated participants (p<0.001). A total of 1,075 patients (26.3 percent) in the statin-treated cohort developed diabetes (average annual incidence rate, 30.6 events per 1,000 person-years).

With increasing fitness, the adjusted risk progressively decreased and was 34 percent lower for High-fit patients compared with the Least-fit (hazard ratio [HR], 0.66; 95 percent CI, 0.53 to 0.82; p<0.001) group. Compared with the nonstatin cohort, the risk of diabetes was elevated only in the Least-fit (HR, 1.50; 1.30 to 1.73; p<0.001) and Low-fit patients (HR, 1.22; 1.06 to 1.41; p=0.006).

“Improving fitness may modulate the potential diabetogenic effects of statins,” according to researchers.

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Most Read Articles
Stephen Padilla, 28 Nov 2017
A dietary pattern rich in fresh and dried fruits, nuts and seeds, vegetable oils, and low-fat dairy products appears to lower the incidence rate of insulin resistance, according to an Iran study.
28 Apr 2018
Treatment with teriparatide increases periostin secretion, but it is unclear whether such increase facilitates the effect of the drug on bone, reports a recent study.
Jairia Dela Cruz, 03 Apr 2018
A small cohort study presented at the Royal College of Obstetricians & Gynaecologists (RCOG) World Congress 2018 has reported a 5-year diabetic ketoacidosis (DKA) incidence rate of 4.16 percent in pregnant women with type 1 diabetes mellitus (T1DM), with generally good maternal and neonatal outcomes.
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