Improvement of renal function eases nephrogenic systemic fibrosis
Improvement of nephrogenic systemic fibrosis (NSF) is significantly associated with improvement of renal function either through transplantation or resolution of acute kidney injury with medical management, according to a recent study.
Researchers aimed to determine whether improvement of renal function through successful transplantation or via return of renal function after acute kidney injury will improve NSF, and to further characterize the clinical features and progression of NSF.
In total, eight patients diagnosed with NSF who presented to a single academic tertiary referral centre were identified through a retrospective medical chart review over a 15-year period. Researchers contacted these patients by phone to collect information pertaining to treatment and clinical course of their NSF and renal function. Fisher’s exact test was used for the statistical analysis.
A significant association existed between improved renal function and improvement of NSF (p=0.0286). Four patients had improvement of renal function, and all of them also had improvement of NSF. Two of these patients had end-stage renal disease and a successful kidney transplant, and the other two had acute kidney injury that resolved.
There was no improvement seen in NSF without resolution of kidney function, according to researchers.
These findings should be interpreted in consideration of the study limitations. These included its small sample size and its retrospective design, which increased the potential for selection and recall bias.
“Despite multiple therapeutic approaches for NSF, no single treatment has convincingly shown consistent benefit. The most successful outcomes have been associated with recovery of renal function, although evidence remains limited and past studies have been inconclusive,” researchers noted.