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Improvement of renal function eases nephrogenic systemic fibrosis

22 Jul 2017

Improvement of nephrogenic systemic fibrosis (NSF) is significantly associated with improvement of renal function either through transplantation or resolution of acute kidney injury with medical management, according to a recent study.

Researchers aimed to determine whether improvement of renal function through successful transplantation or via return of renal function after acute kidney injury will improve NSF, and to further characterize the clinical features and progression of NSF.

In total, eight patients diagnosed with NSF who presented to a single academic tertiary referral centre were identified through a retrospective medical chart review over a 15-year period. Researchers contacted these patients by phone to collect information pertaining to treatment and clinical course of their NSF and renal function. Fisher’s exact test was used for the statistical analysis.

A significant association existed between improved renal function and improvement of NSF (p=0.0286). Four patients had improvement of renal function, and all of them also had improvement of NSF. Two of these patients had end-stage renal disease and a successful kidney transplant, and the other two had acute kidney injury that resolved.

There was no improvement seen in NSF without resolution of kidney function, according to researchers.

These findings should be interpreted in consideration of the study limitations. These included its small sample size and its retrospective design, which increased the potential for selection and recall bias.

“Despite multiple therapeutic approaches for NSF, no single treatment has convincingly shown consistent benefit. The most successful outcomes have been associated with recovery of renal function, although evidence remains limited and past studies have been inconclusive,” researchers noted.

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Most Read Articles
5 days ago
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 3 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
5 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.