Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Impaired LV GLS ups mortality risk in patients with secondary mitral regurgitation

25 Feb 2020

Impaired left ventricular (LV) global longitudinal strain (GLS), but not LV ejection fraction (EF), is independently associated with a higher risk of all-cause mortality in patients with secondary mitral regurgitation (MR), a study has shown.

Of the 650 patients (mean age, 66±11 years; 68 percent men) with significant secondary MR included, 334 (51 percent) died during a median follow-up of 56 months (interquartile range, 28–106 months).

Mortality rates at 1-, 2- and 5-year follow-up were significantly higher among patients with a more impaired LV GLS (13 percent, 23 percent and 44 percent, respectively) compared with those with more preserved LV systolic function (5 percent, 14 percent and 31 percent, respectively).

Multivariable analysis revealed an association between increased mortality (HR, 1.337, 95 percent confidence interval [CI], 1.038–1.722; p=0.024) and LV GLS <7.0 percent, but not LVEF ≤30 percent (HR, 1.055, 95 percent CI, 0.794–1.403; p=0.711).

“LV GLS may therefore be useful in the risk stratification of patients with secondary MR,” the investigators said.

This study aimed at showing the prognostic value of LV GLS over LVEF in patients with secondary MR. The participants were subdivided based on their LV GLS value at which the HR for all-cause mortality was >1 using a spline curve analysis (LV GLS <7.0 percent, impaired LV systolic function vs LV LV GLS ≥7.0 percent, preserved LV systolic function.

“LV systolic function may be overestimated in patients with secondary MR when using LVEF,” the investigators noted. “LV GLS is a less load-dependent measure of LV function.”

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.