Most Read Articles
Pearl Toh, 2 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Pearl Toh, 5 days ago
Gefapixant, a first-in-class non-narcotic, oral P2X3 receptor antagonist, significantly reduces cough frequency in patients with refractory or unexplained chronic cough, according to two COUGH* studies presented at ERS 2020.
Roshini Claire Anthony, Yesterday

Treatment with the DPP 1* inhibitor brensocatib prolonged time to exacerbation and reduced exacerbation rates in patients with non-cystic fibrosis bronchiectasis, according to the phase II WILLOW** study presented at ERS 2020.

Pearl Toh, 18 Jan 2020
Almost three-quarters of adverse events (AEs) related to medication errors in over-the-counter (OTC) cough and cold medications (CCMs) for paediatrics required evaluation by healthcare facility and majority of the cases were due to dosing errors, a surveillance study has found, highlighting the need for interventions to mitigate medication errors.

Impaired lung function predicts atrial fibrillation

15 Oct 2019
Current guidelines recommend the use of spirometry to establish an accurate diagnosis of COPD.

The likelihood of atrial fibrillation (AF) appears to be elevated in the context of weaker pulmonary function, a recent study has shown.

The study included 9,631 participants (median age, 50 years; 48.1 percent male) in whom AF was identified using electrocardiography or self-reports of physician diagnoses, either at baseline or throughout the study period. Lung function was measured according to the forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC).

At baseline, AF was present in 59 participants, yielding a prevalence rate of 0.6 percent. This was significantly higher in the lowest vs highest quartile of FEV1% predicted (1.2 percent vs 0.3 percent; p<0.001). This translated to an elevated likelihood of developing the condition (adjusted odds ratio [OR], 5.92, 95 percent CI, 2.22–15.77).

FVC% predicted at baseline had the same effect on AF risk (adjusted OR, 5.40, 2.06–14.20).

During the follow-up period, a total of 162 new AF cases were reported, leading to an incidence rate of 1.7 percent. Kaplan-Meier curves showed that AF incidence was significantly elevated in the lowest vs highest quartile of FEV1% predicted (2.1 percent vs 1.5 percent; log-rank p=0.042). No such effect was reported for FVC% predicted.

Cox regression analyses confirmed these findings. FEV1% predicted was significantly associated with a greater risk of incident AF (adjusted hazard ratio [HR], 1.59, 1.02–2.50), while FVC% predicted was not (adjusted HR, 1.34, 0.86–2.09).

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Most Read Articles
Pearl Toh, 2 days ago
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Pearl Toh, 5 days ago
Gefapixant, a first-in-class non-narcotic, oral P2X3 receptor antagonist, significantly reduces cough frequency in patients with refractory or unexplained chronic cough, according to two COUGH* studies presented at ERS 2020.
Roshini Claire Anthony, Yesterday

Treatment with the DPP 1* inhibitor brensocatib prolonged time to exacerbation and reduced exacerbation rates in patients with non-cystic fibrosis bronchiectasis, according to the phase II WILLOW** study presented at ERS 2020.

Pearl Toh, 18 Jan 2020
Almost three-quarters of adverse events (AEs) related to medication errors in over-the-counter (OTC) cough and cold medications (CCMs) for paediatrics required evaluation by healthcare facility and majority of the cases were due to dosing errors, a surveillance study has found, highlighting the need for interventions to mitigate medication errors.