Most Read Articles
22 hours ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 29 Mar 2020
While the 2019 coronavirus disease (COVID-19) is generally mild in children, infants appear to be particularly susceptible to severe and critical infections, a new study has found.
4 days ago
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
Pearl Toh, 2 days ago
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Impaired fasting glucose more predictive of T2DM than MetS

22 Feb 2020
One million deaths in China occur each year as a result of diabetic complications.

Impaired fasting glucose (IFG) appears to be a stronger risk factor for type 2 diabetes mellitus (T2DM) than metabolic syndrome (MetS), reports a new Japan study. The coexistence of the two factors confers the highest T2DM risk.

Researchers prospectively followed 4,131 Japanese workers (mean age, 50 years; 3,417 men) who had no prior history of diabetes. IFG was defined as fasting blood glucose 100–125 mg/dL; MetS was defined as abdominal obesity in combination with two or more metabolic risk factors. Fasting blood glucose or glycated haemoglobin, medications, and self-reports were used to determine incident T2DM.

Over a mean follow-up period of 6.3 years, 240 incident cases of T2DM were reported. In those with MetS, the crude incidence rate of T2DM was 20.2 events per 1,000 person-years, as opposed to only 6.1 events per 1,000 person-years in those without MetS. This corresponded to a fully-adjusted hazard ratio (HR) of 3.1 (95 percent confidence interval [CI], 2.3–4.0), suggesting a significant risk excess.

In comparison, the crude rate of T2DM incidence in those with IFG was 29.0 events per 1,000 person-years, similarly greater than that in the no-IFG participants (5.3 events per 1,000 person-years). The corresponding adjusted HR was 4.5 (95 percent CI, 3.4–5.8).

When looking at participants with neither IFG nor MetS, the population attributable fraction (PAF) of T2DM was greater for IFG than it was for MetS (15.6 percent [95 percent CI, 10.1–20.7] vs 9.1 percent [95 percent CI, 3.8–14.2]). The presence of both, however, yielded the highest PAF of 29.7 percent (95 percent CI, 23.0–35.8).

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Most Read Articles
22 hours ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 29 Mar 2020
While the 2019 coronavirus disease (COVID-19) is generally mild in children, infants appear to be particularly susceptible to severe and critical infections, a new study has found.
4 days ago
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
Pearl Toh, 2 days ago
It takes just less than 4 days for COVID-19 to spread from one person to another and cause symptoms, and more than 10 percent of the cases are infected by a person who has caught the virus but yet to show symptoms, recent studies suggest.