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Immunosuppressive therapy for IMID does not worsen disease in COVID-19 patients

03 Dec 2020

A recent study has shown that immunosuppressive (IS) therapies for immune-mediated inflammatory diseases (IMIDs) do not increase the risk of SARS-CoV-2 or severe sequelae when controlling for other factors. In addition, tumour necrosis factor α inhibitors may lower the risk of severe infection.

“Finite clinical data and understanding of COVID-19 immunopathology has led to limited, opinion-based recommendations for the management of IMID [patients] receiving IS therapeutics,” the authors said.

A retrospective cohort analysis was performed to determine if IS therapeutic type influences COVID-19 risk among IMID patients. Participants included Henry Ford Health System patients who tested positive for COVID-19 between 1 February and 18 April 2020 and were treated with IS medication for IMID.

Then, the authors combined the therapeutic class of IS medication, comorbidities, and demographic factors into multivariate models to determine the predictors of COVID-19 infection, admission, ventilation, and mortality.

A total of 213 patients with IMID were included, of whom 36.2 percent tested positive for COVID-19. Of note, these patients were not more likely to be hospitalized or need ventilation relative to the general population.

IS therapeutic did not exacerbate the course of disease after multivariate correction, but multidrug regimens and biologics were predictive of an increased and decreased rate of hospitalization, respectively, with the latter driven by tumour necrosis factor α inhibitors.

“A single-centre study somewhat limits the generalization to community-based settings. Only patients tested for COVID-19 were analysed,” the authors noted.

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Most Read Articles
Roshini Claire Anthony, 01 Dec 2020

An evidence-based, multifaceted intervention aimed at reducing haemodialysis catheter-related bloodstream infections (HD-CRBSIs) failed to improve this outcome, results of the REDUCCTION* trial showed.

Pearl Toh, 4 days ago
While it is well known that COVID-19 illness is associated with coagulopathy, the optimal anticoagulation strategy remains elusive, and two studies presented at the ASH 2020 Congress further add to the growing debate on the appropriate anticoagulant dose for hospitalized patients with COVID-19.
Tristan Manalac, Yesterday
People are more likely to follow social distancing measures for the novel coronavirus disease (COVID-19) pandemic when they thought that their friends and family did the same, too, according to a new study.