Most Read Articles
14 Sep 2020
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


27 Sep 2019
Quadrivalent influenza vaccine (split virion, inactivated) 0.5 mL inj
Stephen Padilla, 27 May 2020
Use of oral fluconazole in the first trimester does not lead to oral clefts or conotruncal malformations but is associated with musculoskeletal malformations, a study has shown.
Stephen Padilla, 17 Dec 2019
The use of aspirin for primary prevention in patients without known cardiovascular diseases (CVDs) significantly reduces the risk of myocardial infarction (MI) but increases that of major bleeding and haemorrhagic stroke, according to a meta-analysis.

Immunosuppressive, corticosteroid use ups herpes zoster risk in Filipinos with SLE

17 Dec 2019

Among Filipino patients with systemic lupus erythematosus (SLE), the use of immunosuppressive and corticosteroid contributes to an increased risk of developing herpes zoster (HZ) infection, a study has found. The risk is even higher in lupus nephritis patients exposed to intravenous cyclophosphamide and mycophenolate mofetil (MMF).

The study included 65 adult SLE patients (mean age, 36.75 years; 93.8 percent female) who developed HZ and 130 matched SLE controls without HZ seen at the University of Santo Tomas Lupus Clinics. Researchers evaluated clinical characteristics, SLE disease activity and immunosuppressive in relation to the risk of HZ.

Mean SLE disease duration at first HZ infection was 6.1 years, and four patients had more than one episode of HZ. The infection was localized in most patients (n=63; 97 percent), and two patients (3 percent) disseminated HZ infections.

Compared with those in the non-HZ group, patients in HZ group were exposed to higher doses of prednisone (mean, 18.62 vs 11.73 mg/d; p<0.001) and more frequently used cyclophosphamide (19/65 vs 7/130 patients; p<0.001). Exposure to the combination of cyclophosphamide plus MMF among lupus nephritis patients was associated with the highest risk of HZ infection.

On the other hand, hydroxychloroquine use reduced the risk of HZ by 87 percent (adjusted odds ratio, 0.13; p=0.003). SLE disease activity showed no direct association with the risk.

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Most Read Articles
14 Sep 2020
Osteoarthritis (OA) is the most common condition affecting the joints. Dr Lee Eu Jin, an Orthopaedic Surgeon from Liberty Orthopaedic Clinic at Mount Elizabeth Medical Centre, Singapore, shares his insights with Pearl Toh on how to manage OA in the primary care setting.


27 Sep 2019
Quadrivalent influenza vaccine (split virion, inactivated) 0.5 mL inj
Stephen Padilla, 27 May 2020
Use of oral fluconazole in the first trimester does not lead to oral clefts or conotruncal malformations but is associated with musculoskeletal malformations, a study has shown.
Stephen Padilla, 17 Dec 2019
The use of aspirin for primary prevention in patients without known cardiovascular diseases (CVDs) significantly reduces the risk of myocardial infarction (MI) but increases that of major bleeding and haemorrhagic stroke, according to a meta-analysis.