Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 4 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.

Immediate, delayed breast reconstruction equally safe

5 days ago

Immediate and delayed autologous breast reconstruction yield similar rates of complications in the context of postmastectomy radiation therapy (PMRT), a new meta-analysis reports.

“Given the patient benefits incurred by an immediate reconstruction algorithm, immediate autologous breast reconstruction should be considered as a viable treatment option in patients requiring PMRT,” the researchers said.

Searching through the databases of PubMed, Embase, Medline, The Cochrane Library, Google Scholar, Scopus, and Web of Science, the researchers identified 44 studies eligible for quantitative analysis. Cumulatively, 3,473 total patients were included, of whom 1,927 underwent immediate and 1,546 delayed reconstruction.

Outcomes were early (flap loss, fat necrosis, seroma, etc) and late (fibrosis, severe asymmetry, hyperpigmentation, etc) complications.

In general, complications occurred at comparable rates between the immediate and delayed reconstruction groups. Fat necrosis, for example, was observed in 14.91 percent and 8.12 percent of patients undergoing the respective procedures (p=0.076).

The same was true for flap loss (immediate vs delayed: 0.99 percent vs 1.80 percent; p=0.295), haematoma (1.91 percent vs 1.14 percent; p=0.247), and thrombosis (1.51 percent vs 3.36 percent; p=0.150).

Notably, infections occurred in 11.66 percent and 4.68 percent of patients receiving immediate and delayed reconstruction, respectively. However, the large mean difference still failed to reach statistical significance (p=0.155).

The only exception was seroma, which occurred at a significantly lower frequency in women opting for immediate reconstruction (2.69 percent vs 10.57 percent; p=0.042).

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Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 4 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.