Most Read Articles
07 May 2021
Both denosumab and alendronic acid fall short of reducing disease progression in patients with calcific aortic stenosis, a study has shown.
Yesterday
A systematic review of randomized controlled trials (RCTs) has found no conclusive evidence that the anti-inflammatory effect of coffee plays a major role in the reduction of all-cause death noted in observational studies.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
08 May 2021
The effect of cannabidiol (CBD) in the treatment of patients with Lennox–Gastaut syndrome may occur within 7 days of initiation, and most adverse events resolve within a 14-week period, a study reports.

Immediate, delayed breast reconstruction equally safe

04 May 2021

Immediate and delayed autologous breast reconstruction yield similar rates of complications in the context of postmastectomy radiation therapy (PMRT), a new meta-analysis reports.

“Given the patient benefits incurred by an immediate reconstruction algorithm, immediate autologous breast reconstruction should be considered as a viable treatment option in patients requiring PMRT,” the researchers said.

Searching through the databases of PubMed, Embase, Medline, The Cochrane Library, Google Scholar, Scopus, and Web of Science, the researchers identified 44 studies eligible for quantitative analysis. Cumulatively, 3,473 total patients were included, of whom 1,927 underwent immediate and 1,546 delayed reconstruction.

Outcomes were early (flap loss, fat necrosis, seroma, etc) and late (fibrosis, severe asymmetry, hyperpigmentation, etc) complications.

In general, complications occurred at comparable rates between the immediate and delayed reconstruction groups. Fat necrosis, for example, was observed in 14.91 percent and 8.12 percent of patients undergoing the respective procedures (p=0.076).

The same was true for flap loss (immediate vs delayed: 0.99 percent vs 1.80 percent; p=0.295), haematoma (1.91 percent vs 1.14 percent; p=0.247), and thrombosis (1.51 percent vs 3.36 percent; p=0.150).

Notably, infections occurred in 11.66 percent and 4.68 percent of patients receiving immediate and delayed reconstruction, respectively. However, the large mean difference still failed to reach statistical significance (p=0.155).

The only exception was seroma, which occurred at a significantly lower frequency in women opting for immediate reconstruction (2.69 percent vs 10.57 percent; p=0.042).

Editor's Recommendations
Most Read Articles
07 May 2021
Both denosumab and alendronic acid fall short of reducing disease progression in patients with calcific aortic stenosis, a study has shown.
Yesterday
A systematic review of randomized controlled trials (RCTs) has found no conclusive evidence that the anti-inflammatory effect of coffee plays a major role in the reduction of all-cause death noted in observational studies.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
08 May 2021
The effect of cannabidiol (CBD) in the treatment of patients with Lennox–Gastaut syndrome may occur within 7 days of initiation, and most adverse events resolve within a 14-week period, a study reports.