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Iatrogenic exposure, predisposing condition common among kids, teens with NMSC

03 Aug 2019
Scientists discover a "sunscreen gene" that has a tumour-suppressing action against skin cancer

Iatrogenic exposure or having a predisposing condition often correlates with nonmelanoma skin cancer (NMSC) in children or young adults, reports a recent study.

The multicentre, retrospective, case-control study included 124 paediatric NMSC patients (median age, 13.2 years; 53 percent male), most of whom had basal cell carcinoma (BCC; n=95; median age, 12.2 years; 54 percent female). Those with squamous cell carcinoma (SCC; n=40) were just as likely to be female (55 percent) but were older (median age, 14.1 years).

Most of the participants (70 percent; n=87) had at least one identifiable risk factor, such as a genetic condition (44 percent), skin lesion (10 percent) and/or iatrogenic exposure (29 percent), while the remaining 30 percent did not. The most common genetic conditions in the BCC and SCC subgroups were basal cell nevus syndrome and xeroderma pigmentosum, respectively.

In terms of iatrogenic risk factors, SCC patients were significantly more likely to have undergone prolonged immunosuppression (30 percent vs 0 percent; p=0.0002) or received voriconazole (15 percent vs 0 percent; p=0.026) than age- and sex-matched controls. In the BCC subgroup, radiation therapy (20 percent vs 1 percent; p0.0001) or chemotherapy (20 percent vs 1 percent; p<0.0001) were significantly more common than in matched controls.

There were six deaths overall: three in the SCC group and two in the BCC group. One patient with both SCC and BCC died. Skin cancer-related or associated therapies were responsible for one death. Survival rate was significantly lower in those who were treated with voriconazole (p=0.001).

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Most Read Articles
5 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.
Jairia Dela Cruz, 06 Sep 2019
Low-dose dexamethasone and prednisolone are equally effective in the treatment of croup in children, according to data from the Topdog* trial.
5 days ago
Early brain injury and at least one sensorimotor immaturity precede cerebral palsy (CP) in very preterm infants and may be considered as reliable predictors, a recent study has found.
Jairia Dela Cruz, 04 Sep 2019
Parenteral antibiotic therapy duration for bacteraemic urinary tract infection (UTI) in young infants may be safely shortened, according to a recent study showing that recurrence and readmission or emergency department revisitation rates are comparable between a ≤7-day and a longer therapy course.