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Hysterectomy, oophorectomy up risk of dyslipidaemia

09 Sep 2018

Women who have had hysterectomies may be at an elevated risk of developing dyslipidaemia, a recent study has shown.

Drawing from the National Health Insurance database of Taiwan, researchers established a cohort of 7,005 women (mean age 46.9±9.00 years) who had undergone a hysterectomy or an oophorectomy. Of these, 5,887 had a hysterectomy alone, 556 had an oophorectomy alone and 563 underwent both operations. A comparison cohort of 28,024 women (mean age 46.9±9.01 years) was also established.

Kaplan-Meier analysis revealed that the incidence of hyperlipidaemia was significantly higher in women who had undergone hysterectomy than in the comparison group (p<0.0001). The incidence density of hyperlipidaemia was almost 1.3-times greater in the hysterectomy vs comparison groups (3.43 vs 2.65 per 100 person-years).

Similar trends were observed for women who received oophorectomy alone (3.51 vs 2.65 per 100 person-years) and those who underwent both procedures (4.93 vs 2.65 per 100 person-years).

Cox proportional hazards regression analysis provided further confirmation of these findings. The risk of developing hyperlipidaemia was significantly higher in women who received hysterectomy (adjusted hazard ratio [HR], 1.27; 95 percent CI, 1.19–1.45). The same was true for participants who underwent both operations (HR, 1.51; 1.31–1.75).

Risk elevation was also observed in women who received oophorectomy alone, though statistical significance was not achieved (adjusted HR, 1.11; 0.93–1.32).

Stratifying the analysis by age revealed that hyperlipidaemia incidence was higher in participants aged 45–64 years. However, surgery appeared to have more effect on dyslipidaemia in women <45 years of age.

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