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Hysterectomy, oophorectomy up risk of dyslipidaemia

09 Sep 2018

Women who have had hysterectomies may be at an elevated risk of developing dyslipidaemia, a recent study has shown.

Drawing from the National Health Insurance database of Taiwan, researchers established a cohort of 7,005 women (mean age 46.9±9.00 years) who had undergone a hysterectomy or an oophorectomy. Of these, 5,887 had a hysterectomy alone, 556 had an oophorectomy alone and 563 underwent both operations. A comparison cohort of 28,024 women (mean age 46.9±9.01 years) was also established.

Kaplan-Meier analysis revealed that the incidence of hyperlipidaemia was significantly higher in women who had undergone hysterectomy than in the comparison group (p<0.0001). The incidence density of hyperlipidaemia was almost 1.3-times greater in the hysterectomy vs comparison groups (3.43 vs 2.65 per 100 person-years).

Similar trends were observed for women who received oophorectomy alone (3.51 vs 2.65 per 100 person-years) and those who underwent both procedures (4.93 vs 2.65 per 100 person-years).

Cox proportional hazards regression analysis provided further confirmation of these findings. The risk of developing hyperlipidaemia was significantly higher in women who received hysterectomy (adjusted hazard ratio [HR], 1.27; 95 percent CI, 1.19–1.45). The same was true for participants who underwent both operations (HR, 1.51; 1.31–1.75).

Risk elevation was also observed in women who received oophorectomy alone, though statistical significance was not achieved (adjusted HR, 1.11; 0.93–1.32).

Stratifying the analysis by age revealed that hyperlipidaemia incidence was higher in participants aged 45–64 years. However, surgery appeared to have more effect on dyslipidaemia in women <45 years of age.

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Most Read Articles
01 Sep 2018

Gangliosides and docosahexaenoic acid (DHA) play critical roles in early childhood brain development. 

30 Nov 2017
Gestational diabetes was positively associated with cardiovascular disease (CVD) later in life, according to a new study. Adhering to a healthy lifestyle may, however, offset this risk.