Most Read Articles
30 Aug 2020
Diabetes bears an increased hazard of developing kidney cancer among postmenopausal women, but this association is only limited to those without obesity, a study has shown.
11 Jul 2020
Individuals who eat large amounts of vegetables and fruits, wheat, nuts, and dairy products are better protected against insulin resistance, diabetes mellitus, and excessive abdominal fat as compared with those who consume lots of fast foods, alcoholic beverages, and desserts—a dietary pattern described to promote metabolic abnormalities and disorders, as reported in a study.
22 Aug 2020
A weakened correlation between fructosamine and glycated haemoglobin (HbA1c) levels may be indicative of obesity in type 2 diabetes patients, reports a new study.
29 Aug 2020
Sodium-glucose co-transporters (SGLT) 2 and 1/2 inhibitors help improve glycaemic control in patients with type 1 diabetes (T1D), reports a new meta-analysis.

Hypothyroidism ups risk of all-cause mortality in older patients

02 May 2020

Elderly patients with hypothyroidism are at increased risk of all-cause mortality, but not cardiovascular mortality, results of a systematic review and meta-analysis have shown.

The investigators searched the databases of PubMed, Embase, Cochrane Library, Scopus and Web of Science from inception until 10 May 2019 for studies assessing the association between hypothyroidism and all-cause or cardiovascular mortality in the elderly population (ages ≥60 years).

Data were extracted and the quality of studies was assessed independently by two reviewers. Relative risk (RR) was retrieved for synthesis, while a random-effects model was used for meta-analysis.

Twenty-seven cohort studies involving a total of 1,114,638 participants were included in the meta-analysis. Hypothyroidism was significantly associated with a higher risk of all-cause mortality compared with euthyroidism (pooled RR, 1.26, 95 percent confidence interval [CI], 1.15–1.37). On the other hand, cardiovascular mortality did not significantly differ between patients with hypothyroidism and those with euthyroidism (pooled RR, 1.10, 95 percent CI, 0.84–1.43).

In subgroup analysis, an association was found between increased all-cause mortality and overt hypothyroidism (pooled RR, 1.10, 95 percent CI, 1.01–1.20) rather than subclinical hypothyroidism (pooled RR, 1.14, 95 percent CI, 0.92–1.41).

Heterogeneity stemmed from various study designs (ie, prospective and retrospective) and geographic locations (ie, Europe, Asia, Oceania and North America).

“We observed considerable heterogeneity, so caution is needed when interpreting the results,” the investigators said. “Further prospective, large-scale, high-quality studies are warranted to confirm these findings.”

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
30 Aug 2020
Diabetes bears an increased hazard of developing kidney cancer among postmenopausal women, but this association is only limited to those without obesity, a study has shown.
11 Jul 2020
Individuals who eat large amounts of vegetables and fruits, wheat, nuts, and dairy products are better protected against insulin resistance, diabetes mellitus, and excessive abdominal fat as compared with those who consume lots of fast foods, alcoholic beverages, and desserts—a dietary pattern described to promote metabolic abnormalities and disorders, as reported in a study.
22 Aug 2020
A weakened correlation between fructosamine and glycated haemoglobin (HbA1c) levels may be indicative of obesity in type 2 diabetes patients, reports a new study.
29 Aug 2020
Sodium-glucose co-transporters (SGLT) 2 and 1/2 inhibitors help improve glycaemic control in patients with type 1 diabetes (T1D), reports a new meta-analysis.