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Roshini Claire Anthony, 3 days ago

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Tristan Manalac, 6 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
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Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
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Hypothyroidism in mothers tied to heightened risk of developing autism in children

13 May 2018

Maternal hypothyroidism contributes to an increased risk of developing autism spectrum disorder (ASD) in children in a manner dependent on race–ethnicity, according to a retrospective US cohort study.

The study included 397,201 children who were delivered from 1991 to 2011 and remained Kaiser Permanente Southern California health plan members from 1993 to 2014. During the study period, the prevalence of chronic hypothyroidism in mothers was 2.2 percent. There were 6,475 children who developed ASD. Mothers of children with ASD were older, better educated, at lower parity and received prenatal care earlier, and their children were born earlier and more often males of white race.

ASD rates were higher in children born to hypothyroid mothers than in children born to those without the diagnosis (2.14 vs 1.62/1,000 person-years). In Cox proportional hazards models, maternal hypothyroidism, whether diagnosed before or during pregnancy, increased the risk of ASD in offspring by about 30 percent (adjusted hazard ratio [HR], 1.31; 95 percent CI, 1.13–1.53).

The association between maternal hypothyroidism and ASD was seen among both boys (3.93 vs 2.62/1,000 person-years; adjusted HR, 1.27; 1.07–1.50) and girls (1.10 vs 0.61/1,000 person-years; adjusted HR, 1.51; 1.10–2.08). Among women diagnosed with hypothyroidism during pregnancy, normal thyroid-stimulating hormone and free thyroxine levels were not associated with an increased risk of ASD in children.

Prenatal hypothyroidism was associated with an increased risk of ASD in children of Hispanics (adjusted HR, 1.09; 1.01–1.17) and women of other/mixed race–ethnicity (adjusted HR, 1.08; 1.00–1.16) than in children of white women.

According to researchers, management of maternal hypothyroidism may help ameliorate the risk of ASD.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 6 days ago
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
Yesterday
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
2 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.