Most Read Articles
Roshini Claire Anthony, 6 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
4 days ago
Heeding the advice to eat more vegetables has led to an increase in consumption above the Australian Dietary recommendation of ~375 g/day among overweight participants, a recent study has shown. Tomatoes are a common choice regardless of the time of year, but selections change over time.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.

Hypothyroidism in mothers tied to heightened risk of developing autism in children

13 May 2018

Maternal hypothyroidism contributes to an increased risk of developing autism spectrum disorder (ASD) in children in a manner dependent on race–ethnicity, according to a retrospective US cohort study.

The study included 397,201 children who were delivered from 1991 to 2011 and remained Kaiser Permanente Southern California health plan members from 1993 to 2014. During the study period, the prevalence of chronic hypothyroidism in mothers was 2.2 percent. There were 6,475 children who developed ASD. Mothers of children with ASD were older, better educated, at lower parity and received prenatal care earlier, and their children were born earlier and more often males of white race.

ASD rates were higher in children born to hypothyroid mothers than in children born to those without the diagnosis (2.14 vs 1.62/1,000 person-years). In Cox proportional hazards models, maternal hypothyroidism, whether diagnosed before or during pregnancy, increased the risk of ASD in offspring by about 30 percent (adjusted hazard ratio [HR], 1.31; 95 percent CI, 1.13–1.53).

The association between maternal hypothyroidism and ASD was seen among both boys (3.93 vs 2.62/1,000 person-years; adjusted HR, 1.27; 1.07–1.50) and girls (1.10 vs 0.61/1,000 person-years; adjusted HR, 1.51; 1.10–2.08). Among women diagnosed with hypothyroidism during pregnancy, normal thyroid-stimulating hormone and free thyroxine levels were not associated with an increased risk of ASD in children.

Prenatal hypothyroidism was associated with an increased risk of ASD in children of Hispanics (adjusted HR, 1.09; 1.01–1.17) and women of other/mixed race–ethnicity (adjusted HR, 1.08; 1.00–1.16) than in children of white women.

According to researchers, management of maternal hypothyroidism may help ameliorate the risk of ASD.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
4 days ago
Heeding the advice to eat more vegetables has led to an increase in consumption above the Australian Dietary recommendation of ~375 g/day among overweight participants, a recent study has shown. Tomatoes are a common choice regardless of the time of year, but selections change over time.
21 Jul 2018
Although many patients with atopic dermatitis (AD) use antihistamines, no high-level evidence exists to prove that nonsedating antihistamines reduce itch in patients with AD or provide benefit in controlling AD symptoms, except perhaps sleep and AD comorbidities such as allergic rhinitis, according to a study.