Most Read Articles
Roshini Claire Anthony, 4 days ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

Tristan Manalac, 5 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 06 Dec 2019
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
Jairia Dela Cruz, 3 days ago
Use of isatuximab (Isa) in combination with pomalidomide and dexamethasone (PomDex) appears to lead to more favourable outcomes in elderly patients with relapsed/refractory multiple myeloma (RRMM) as compared with PomDex alone, according to the results of a subgroup analysis of the ICARIA-MM trial presented at the 61st Annual Meeting of the American Society of Hematology (ASH 2019).

Hypothyroidism associated with sleep apnoea

21 Oct 2019

A significant association exists between hypothyroidism and sleep apnoea after adjusting for potential confounding variables, results of a US study have shown.

This cross-sectional study utilized the US National Health and Nutrition Examination Survey from 2007 to 2008 and included all participants aged ≥18 years who met the inclusion criteria.

Participants not on antithyroid medication with a thyroid-stimulating hormone (TSH) >5.6 mIU/L and those on thyroid hormone replacement regardless of TSH were categorized as hypothyroid. Those not on thyroid hormone replacement or antithyroid medication with a TSH ≥0.34 and ≤5.6 mIU/L were categorized as euthyroid.

Sleep apnoea diagnosis was based on the participants’ response when asked whether they had been diagnosed with the said condition by their doctors. The association between hypothyroidism and sleep apnoea was examined through multivariate logistic regression analysis.

Of the 5,515 adults who were included in the data analysis, 9.47 percent had been diagnosed with hypothyroidism and 1.19 percent with hyperthyroidism. Hypothyroidism was found to be significantly associated with sleep apnoea (odds ratio, 1.88, 95 percent CI, 1.24–2.84; p<0.01) in multivariate logistic regression analysis adjusted for body mass index, healthcare access, demographics, socioeconomic factors, smoking, alcohol use and other comorbidities.

A case study involving a 79-year-old man with significant cardiovascular comorbidities who presented with out-of-hospital respiratory arrest was found to have severe obstructive sleep apnoea and hypothyroidism. This case indicated that the combination of sleep apnoea and hypothyroidism can result in “catastrophic manifestation.” [BMJ Case Rep 2019;doi:10.1136/bcr-2019-230163]

Moreover, “the unusually long apnoea could be a feature prompting further workup for possible hypothyroidism,” the researchers said. [BMJ Case Rep 2019;doi:10.1136/bcr-2019-230163]

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Most Read Articles
Roshini Claire Anthony, 4 days ago

Patients undergoing chemotherapy for breast or haematological cancers could potentially reduce their risk of chemotherapy-related cardiotoxicity with the use of angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists (ARBs), or beta-blockers as primary prevention, according to a systematic review and meta-analysis presented at the recent EuroEcho 2019 conference.

Tristan Manalac, 5 days ago
Users of electronic nicotine delivery systems are likely to have received a diagnosis of clinical depression in the past, according to a recent study.
Pearl Toh, 06 Dec 2019
Getting just under one extra hour of sleep per night can go a long way for the health of college students, who are often sleep-deprived, a study suggests.
Jairia Dela Cruz, 3 days ago
Use of isatuximab (Isa) in combination with pomalidomide and dexamethasone (PomDex) appears to lead to more favourable outcomes in elderly patients with relapsed/refractory multiple myeloma (RRMM) as compared with PomDex alone, according to the results of a subgroup analysis of the ICARIA-MM trial presented at the 61st Annual Meeting of the American Society of Hematology (ASH 2019).