Most Read Articles
4 days ago
Children with high dental anxiety are more likely to develop dental diseases, which, in turn, negatively affect the family’s quality of life, a recent study has found.
2 days ago
Exposure to corticosteroids in patients with autoimmune hepatitis (AIH) appears to contribute to increased risks of cataract, diabetes and bone fractures, a study has found. Notably, the fracture risk is elevated at low doses, while the risk of adverse events overall is dose-dependent and is reversible.
14 Nov 2019
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
3 days ago
Supplementation with oral nano vitamin D appears to moderate disease activity and severity grade of patients with active ulcerative colitis (UC), suggests a study, adding that this association is more evident in those achieving a target vitamin D level of 40 ng/mL.

Hypothyroidism associated with sleep apnoea

21 Oct 2019

A significant association exists between hypothyroidism and sleep apnoea after adjusting for potential confounding variables, results of a US study have shown.

This cross-sectional study utilized the US National Health and Nutrition Examination Survey from 2007 to 2008 and included all participants aged ≥18 years who met the inclusion criteria.

Participants not on antithyroid medication with a thyroid-stimulating hormone (TSH) >5.6 mIU/L and those on thyroid hormone replacement regardless of TSH were categorized as hypothyroid. Those not on thyroid hormone replacement or antithyroid medication with a TSH ≥0.34 and ≤5.6 mIU/L were categorized as euthyroid.

Sleep apnoea diagnosis was based on the participants’ response when asked whether they had been diagnosed with the said condition by their doctors. The association between hypothyroidism and sleep apnoea was examined through multivariate logistic regression analysis.

Of the 5,515 adults who were included in the data analysis, 9.47 percent had been diagnosed with hypothyroidism and 1.19 percent with hyperthyroidism. Hypothyroidism was found to be significantly associated with sleep apnoea (odds ratio, 1.88, 95 percent CI, 1.24–2.84; p<0.01) in multivariate logistic regression analysis adjusted for body mass index, healthcare access, demographics, socioeconomic factors, smoking, alcohol use and other comorbidities.

A case study involving a 79-year-old man with significant cardiovascular comorbidities who presented with out-of-hospital respiratory arrest was found to have severe obstructive sleep apnoea and hypothyroidism. This case indicated that the combination of sleep apnoea and hypothyroidism can result in “catastrophic manifestation.” [BMJ Case Rep 2019;doi:10.1136/bcr-2019-230163]

Moreover, “the unusually long apnoea could be a feature prompting further workup for possible hypothyroidism,” the researchers said. [BMJ Case Rep 2019;doi:10.1136/bcr-2019-230163]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
4 days ago
Children with high dental anxiety are more likely to develop dental diseases, which, in turn, negatively affect the family’s quality of life, a recent study has found.
2 days ago
Exposure to corticosteroids in patients with autoimmune hepatitis (AIH) appears to contribute to increased risks of cataract, diabetes and bone fractures, a study has found. Notably, the fracture risk is elevated at low doses, while the risk of adverse events overall is dose-dependent and is reversible.
14 Nov 2019
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
3 days ago
Supplementation with oral nano vitamin D appears to moderate disease activity and severity grade of patients with active ulcerative colitis (UC), suggests a study, adding that this association is more evident in those achieving a target vitamin D level of 40 ng/mL.