Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Hypothyroidism associated with sleep apnoea

21 Oct 2019

A significant association exists between hypothyroidism and sleep apnoea after adjusting for potential confounding variables, results of a US study have shown.

This cross-sectional study utilized the US National Health and Nutrition Examination Survey from 2007 to 2008 and included all participants aged ≥18 years who met the inclusion criteria.

Participants not on antithyroid medication with a thyroid-stimulating hormone (TSH) >5.6 mIU/L and those on thyroid hormone replacement regardless of TSH were categorized as hypothyroid. Those not on thyroid hormone replacement or antithyroid medication with a TSH ≥0.34 and ≤5.6 mIU/L were categorized as euthyroid.

Sleep apnoea diagnosis was based on the participants’ response when asked whether they had been diagnosed with the said condition by their doctors. The association between hypothyroidism and sleep apnoea was examined through multivariate logistic regression analysis.

Of the 5,515 adults who were included in the data analysis, 9.47 percent had been diagnosed with hypothyroidism and 1.19 percent with hyperthyroidism. Hypothyroidism was found to be significantly associated with sleep apnoea (odds ratio, 1.88, 95 percent CI, 1.24–2.84; p<0.01) in multivariate logistic regression analysis adjusted for body mass index, healthcare access, demographics, socioeconomic factors, smoking, alcohol use and other comorbidities.

A case study involving a 79-year-old man with significant cardiovascular comorbidities who presented with out-of-hospital respiratory arrest was found to have severe obstructive sleep apnoea and hypothyroidism. This case indicated that the combination of sleep apnoea and hypothyroidism can result in “catastrophic manifestation.” [BMJ Case Rep 2019;doi:10.1136/bcr-2019-230163]

Moreover, “the unusually long apnoea could be a feature prompting further workup for possible hypothyroidism,” the researchers said. [BMJ Case Rep 2019;doi:10.1136/bcr-2019-230163]

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.