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Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

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Hypothermic oxygenated perfusion improves DCD livers for transplantation

24 Dec 2018
Patients with a higher MELD score are given priority for a liver transplant.

Hypothermic oxygenated perfusion (HOPE)-treated human livers donated after circulatory death (DCD) show superior function over untreated livers, a new study has shown.

Researchers evaluated 50 HOPE-treated DCD, 50 donated after brain death (DBD) and 50 untreated DCD liver transplants. Study endpoints included post-transplant complications, nontumour related patient death and graft loss.

Untreated DCD livers required significantly more median transfusions of fresh frozen plasma (6 vs 0; p<0.0001) during operation despite a comparable duration of surgery. HOPE-treated DCD transplants also resulted in a significantly lower lactate level at the end of the transplantation procedure (p<0.0001).

International normalized ratio (INR)1 day after transplantation was likewise significantly reduced in those who received the HOPE-treated DCD livers (p<0.0001). These findings indicated superior function over untreated transplants. There was no between-group difference in peak 7-day alanine aminotransferase release.

In terms of complications, acute rejections were significantly more common in untreated DCD livers relative to HOPE-treated transplants (p=0.0019). Median alkaline phosphatase levels 6 months after the procedure were similarly significantly lower in those who received the treated livers (p=0.049).

Seven cases of graft loss were reported in the untreated DCD group, which was significantly greater than that in the HOPE-treated transplant group (n=0; p=0.0125). Ischaemic cholangiopathy and primary nonfunction were the reasons for graft loss.

Five-year graft survival rates for the untreated and HOPE-treated DCD livers were 74 percent and 94 percent, respectively. HOPE-treated transplants demonstrated comparable overall survival compared with DBD controls.

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Most Read Articles
Roshini Claire Anthony, 5 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
4 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.
5 days ago
There appears to be no clear link between pornography use, even at problematic levels, and erectile dysfunction, a recent US study has shown.