Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
4 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.

Hypoprolactinemia dampens sex drive in women

23 Jul 2020

Low serum prolactin levels may spell trouble for women, with a recent study linking hypoprolactinemia to impaired sexual functioning and well-being. Specifically, libido and arousal wane, and mild depressive symptoms ensue.

Researchers examined three age‐matched groups of young women with normal, regular menstrual cycles: 15 of those with cabergoline‐induced hypoprolactinemia (group A), 25 cabergoline‐treated individuals with prolactin levels within the reference range (group B), and 30 dopamine agonist‐naïve women with normal prolactin levels.

Because of low prolactin levels, the dose of cabergoline in group A, but not in group B, was reduced. Nevertheless, doses did not significantly differ between the two group at baseline (1.24 vs 1.12 mg weekly) and throughout the 6-month follow-up (0.95 vs 1.12 mg weekly).

There were no baseline differences between the groups in age, body mass index, smoking, physical activity, education, occupational activity, type of work, number of sexual partners, number and duration of marriages, number of deliveries and miscarriages, stress exposure, as well as systolic and diastolic blood pressure.

At baseline, the total female sexual function index (FSFI) and all domain scores, as well as the Beck Depression Inventory-II (BDI-II) score, did not differ between groups B and C. In comparison, group A had lower total FSFI score and domain scores for desire and arousal, and higher BDI‐II score.

Compared with those in groups B and C, women with cabergoline‐induced hypoprolactinemia also had lower total testosterone levels and lower values of the free androgen index.

The observed disturbances were reversed when cabergoline dose was reduced and prolactin levels subsequently returned to the reference range. Sexual drive and arousal returned to normal, and mood improved.

The researchers pointed out that the disturbances may have resulted from lactotrope hypofunction, but not from specific properties of cabergoline.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 22 Oct 2020
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
3 days ago
Weight suppression appears to result in future onset of eating disorders characterized by dietary restriction or compensatory weight control behaviours, suggesting weight-suppressed women represent an at-risk group that may benefit from selective prevention programmes, a study has found.
4 days ago
Nocturia is a risk factor for mortality, according to the results of the Nagahama Study, which boasts of a low incidence of missing data and high representation of the general population.