Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum. 

Hypnosis, venlafaxine equally reduce hot flashes; combination not superior to either approach

20 Mar 2017

Hypnosis may produce reductions in hot flashes similar to that achieved with venlafaxine, according to a study, although the combination of these two treatment approaches is not superior to either treatment alone.

The pilot study randomized 71 postmenopausal women to one of four treatment groups: venlafaxine 75 mg plus hypnosis (VH; n=15; mean age 56 years), venlafaxine 75 mg plus sham hypnosis (VSH; n=19; mean age 54 years), placebo pill plus hypnosis (PH; n=22; mean age 54 years) and placebo pill plus sham hypnosis (PSH; n=15; mean age 56 years). Treatment lasted 8 weeks.

All women kept a daily diary in which hot flash severity and frequency were recorded in real time. A General Estimating Equation model facilitated analysis of intrapatient difference in hot flash score (frequency x severity) at 8 weeks—the primary endpoint—using VSH as the referent arm and controlling for baseline hot flashes.

The primary endpoint did not statistically differ in the active treatment arms, PH and VH, when compared with the referent arm VSH (p=0.34 and p=0.05, respectively). Hot flashes decreased by about 50 percent in the PH and VH arms vs 25 percent in the PSH arm. Women in the PSH arm also reported statistically smaller reductions in hot flash score compared with those in the referent VSH arm (p=0.001).

No significant negative side effects were reported during the course of the study.

Hot flashes occur commonly in menopause, affecting up to 75 percent of women including those with a history of cancer. The symptom can be a significant source of bother and distress, negatively affecting quality of life and possibly leading to a loss of productivity. [Lancet 2002;360:1851-1861; Clin Obstet Gynaecol 2007;21:261-274; Climacteric 2015;18:456-469]

Aside from hormonal therapy and nonhormonal alternatives such as serotonergic antidepressants and the anticonvulsant gabapentin, behavioural therapy also shows potential in the management of hot flashes. [N Engl J Med 2016;374:803-806; J Clin Oncol 2002;20:1578-1583; Oncol 2009;27:2831-2837]

The current data provide evidence of the efficacy of hypnosis in the treatment of hot flashes, although more studies are needed to elucidate whether the intervention could be combined with a different low-dose pharmacologic intervention “to provide optimal relief of hot flashes synergistically without ceiling effects and without side effects, or to identify a population who could benefit more from such a combination,” researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum.