Most Read Articles
26 Jun 2020

Achieving standard of care targets, such as reduced levels of low-density lipoprotein cholesterol and glycated haemoglobin, improves outcomes in coronary heart disease patients, a new study has found.

Pearl Toh, 19 Jan 2018
Blood pressure (BP) control can be best achieved with a multilevel, multicomponent approach involving team-based care with physician- and non-physician-led interventions, as well as patient-level strategies, according to findings of a meta-analysis.
Dr. Joseph Delano Fule Robles, 24 Jul 2018

Functional foods benefit the body beyond its nutritional effects, with studies showing that they can improve general state of health and reduce the risk of diseases.

29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.

Hyperuricaemia a strong predictor of hypertension

24 May 2020

Excessive levels of uric acid in the blood are a risk factor for hypertension, independent of alcohol consumption, a study has found.

The analysis involved 7,848 hypertension-free adults (age, 30–74 years; 54.1 percent male) without hypertension who had undergone a medical check-up. Of these, 786 men and 187 women had hyperuricaemia (defined as uric acid >7.0 mg/dl in men, ≥6.0 mg/dl in women, and/or receiving treatment for hyperuricaemia or gout).

Overall, participants with hyperuricaemia had higher systolic and diastolic blood pressure (BP) and were more likely to have estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2, dyslipidaemia, smoking history, be overweight and a heavy alcohol drinker.

A total of 1,679 participants developed hypertension (defined as the first diagnoses of BP ≥140/≥90 mm Hg and/or initiation of antihypertensive drug treatment) over a mean follow-up of 3.99 years. Multivariable logistic regression analyses showed that alcohol consumption was positively associated with the incidence of hypertension in both men (p<0.001) and women (p=0.037).

In Cox proportional hazards models controlling for alcohol consumption, hyperuricaemia emerged as a risk factor for hypertension in men (hazard ratio [HR], 1.37, 95 percent confidence interval [CI], 1.19–1.58) and women (HR, 1.54, 95 percent CI, 1.14–2.06) alike. Compared with nondrinkers, alcohol drinkers of both sexes were at higher risk. 

Among nondrinkers, the HRs for hypertension were 1.29 (95 percent CI, 0.94–1.78) and 1.57 (95 percent CI, 1.11–2.22) in men and women, respectively, with vs without hyperuricaemia. The corresponding HR was 1.88 (95 percent CI, 1.27–2.86) in the group of participants with baseline BP <120/80 mm Hg. The interactions between hyperuricaemia and sex (p=0.534) and between drinking and sex (p=0.713) were not significant.

The findings underscore the potential usefulness of uric acid assessment, regardless of drinking habits, in the prevention of hypertension among men and women, researchers said.

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Most Read Articles
26 Jun 2020

Achieving standard of care targets, such as reduced levels of low-density lipoprotein cholesterol and glycated haemoglobin, improves outcomes in coronary heart disease patients, a new study has found.

Pearl Toh, 19 Jan 2018
Blood pressure (BP) control can be best achieved with a multilevel, multicomponent approach involving team-based care with physician- and non-physician-led interventions, as well as patient-level strategies, according to findings of a meta-analysis.
Dr. Joseph Delano Fule Robles, 24 Jul 2018

Functional foods benefit the body beyond its nutritional effects, with studies showing that they can improve general state of health and reduce the risk of diseases.

29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.