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Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
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Hypertension ups risk of rebleeding after TIPSS

27 Aug 2017
29 sources of inaccuracy have been identified in the measurement of adults’ resting blood pressure in clinical settings.

Preascites and hypertension are independent risk factors for parent ascites, while hypertension is an independent risk factor for rebleeding following transjugular intrahepatic portosystemic stent shunt (TIPSS) therapy, a new cohort study has found.

Records of 124 patients who received TIPSS were used in the study. Participants were then divided into two groups: elderly (n=37; age 60 years; 62.6 percent male) and nonelderly (n=87; age <60 years; 73.6 percent male). Exclusion criteria included unsuccessful and emergency TIPSS treatments.

Propensity score matching was performed between the elderly and nonelderly groups to remove potential confounders. The primary outcome was treatment-related adverse events within 1 year. Total length of stay, postoperative hospital stays and hospital deaths were secondary outcomes.

Multivariate logistic regression revealed that hypertension was a significant independent risk factor for rebleeding (odds ratio [OR], 13.249; 95 percent CI, 1.29 to 136.073; p=0.03).

On the other hand, smoking (OR, 4.48; 1.43 to 14.033; p=0.01) and preascites (OR, 6.7; 2.04 to 22.005; p=0.002) were shown as independent risk factors for patients’ ascites following TIPSS treatment.

There were no significant differences between the elderly and nonelderly groups in terms of therapy-related adverse events such as fever (p=0.266), vomiting (p=0.443), bellyaches (p=0.59), diarrhoea (p=0.151), ascites (p=0.393) and rebleeding (p=0.27), suggesting that age was not a significant risk factor for poor outcomes.

“There are limitations to the present study because of its retrospective design. More patients are needed to match more pairs and increase the credibility of the results,” said researchers. 

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Most Read Articles
Roshini Claire Anthony, 4 days ago

The combined use of piperacillin and tazobactam does not appear to be a suitable alternative to meropenem for patients with bloodstream infections caused by ceftriaxone-resistant Escherichia coli (E. coli) or Klebsiella pneumoniae (K. pneumoniae), according to results of the MERINO* trial.

Tristan Manalac, 19 May 2018
Taking oral antibiotics appears to increase the risk of nephrolithiasis, according to a recent study. Moreover, the risk seems to be compounded for individuals with recent antibiotic exposure and those who were exposed at a younger age.
2 days ago
Patients with inflammatory bowel disease are at increased risk of developing acute myocardial infarction (AMI) or heart failure, although the prevalence of traditional risk factors for such cardiovascular disorders appears to be low, as reported in a recent study.
3 days ago
Early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) leads to better short- and long-term renal outcomes in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN), according to a study, adding that this renal protective effect is independent of RASI’s antihypertensive and antiproteinuric effects.