Most Read Articles
Dr. Joseph Delano Fule Robles, 14 Nov 2017

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

14 Nov 2017
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
6 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.

Hypertension ups risk of developing open-angle glaucoma

08 Mar 2017

Open-angle glaucoma (OAG) is more likely to occur in patients diagnosed with systemic hypertension (HTN) than those without HTN, according to a recent study.

An 11-year nationwide cohort study was conducted to assess the association between OAG and HTN. Included were patients with HTN and a matched comparison cohort from the Korean National Health Insurance Service National Sample Cohort database.

The HTN group consisted of patients who were prescribed antihypertensive medication, or those with systolic blood pressure (SBP) of at least 140 mm Hg or diastolic blood pressure (DBP) of at least 90 mm Hg. The OAG group was composed of patients satisfying the OAG criteria during repeated visits to an ophthalmologist.

Researchers used the Charlson comorbidity index to control for systemic conditions and performed Cox proportional hazard regression analysis.

OAG occurred in 1,961 (2.0 percent) patients in the HTN group and in 1,692 (1.7 percent) in the comparison group (p<0.001). The respective OAG incidence rates in patients with and without HTN were 19.0 and 16.4 per 10,000 person-years.

Based on multivariable Cox model, there was an association between HTN and an increased OAG incidence (adjusted hazard ratio [HR], 1.16; 95 percent CI, 1.09 to 1.24).

Subsequent OAG was more likely to occur in participants with higher SBP (adjusted HR, 1.12 for 120 to 139 mm Hg group; and adjusted HR, 1.20 for ≥140 mm Hg group) than in those who had SBP of <120 mm Hg. In addition, similar trends were seen in participants with higher DBP (adjusted HR, 1.11 for 80 to 89 mm Hg group; and adjusted HR, 1.07 for ≥90 mmHg group) and those with <80 mm Hg DBP.

A study by Newmann-Casey et al had similar observations, which found an increased hazard of developing OAG in individuals with HTN (HR, 1.17; 1.13 to 1.22) or diabetes mellitus (HR, 1.35; 1.21 to 1.50) or in combination (HR, 1.48; 1.39 to 1.58) relative to those without these conditions. [Ophthalmology 2011;118:1318-26]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Dr. Joseph Delano Fule Robles, 14 Nov 2017

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

14 Nov 2017
The 5-year survival rates for human papillomavirus (HPV)-associated cancers vary greatly according to age and race, with Caucasians and younger patients tending to have better survival, according to a recent US study.
6 days ago
Both hatha yoga and a low-FODMAP (Fermentable, Oligo-, Di-, Monosaccharides and Polyol) diet can alleviate gastrointestinal symptoms, as well as improve a range of other psychological and physiological health parameters, in patients with irritable bowel syndrome (IBS), a study has shown.
6 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.