Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
11 Jan 2020
Prevention of glucocorticoid-induced osteoporosis (GIOP) and postmenopausal osteoporosis (PMOP) remains inadequate in patients with rheumatoid arthritis (RA), as shown in a study that evaluated the implementation of the 2003 and 2014 French guidelines on the prevention and treatment of GIOP and the 2012 update of the French guidelines for the treatment of PMOP.

Hypertension in aortic stenosis does not interact with symptoms, functional capacity during ETT

26 Nov 2019

Hypertension is associated with a high cardiovascular disease burden but does not appear to have any impact on symptoms or functional capacity during exercise treadmill test (ETT) in patients with aortic stenosis, results of a study have shown.

“Hypertension does not interfere with the clinical interpretation of exercise testing,” the authors said.

Of the 314 patients included, 229 (73 percent) with hypertension were older and were more likely to have diabetes, hypercholesterolaemia and coronary artery disease, larger left atrial diameter, higher left ventricular (LV) mass, and a higher proportion of LV hypertrophy than normotensive patients.

Hypertension and clinic systolic blood pressure (SBP) did not correlate with revealed symptoms in a univariate logistic regression analysis.

In a multivariate logistic regression analysis, lower peak SBP (odds ratio [OR], 1.02, 95 percent confidence interval [CI], 1.00–1.04; p=0.017) and rapid early rise in heart rate (OR, 15.03, 95 percent CI, 6.23–36.24; p<0.001) correlated with an increased risk of revealed symptoms, whereas the use of antihypertensive treatment led to a reduced risk of revealed symptoms (OR, 0.40, 95 percent CI, 0.18–0.89; p=0.025), independent of age, obesity, LV ejection fraction and aortic valve area.

In a linear regression analysis, the association between hypertension and lower metabolic equivalents (β, –0.06; p=0.311) was not maintained after adjusting for age, sex and body mass index.

This study included 314 patients (mean age, 65±12 years; 68 percent men) with moderate or severe asymptomatic aortic stenosis who underwent baseline echocardiography and ETT. Hypertension was defined as a history of elevated BP, part or current treatment with antihypertensive agents, or a BP at the baseline clinic visit >140/90 mm Hg.

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Most Read Articles
Pearl Toh, 31 Dec 2019
Adding the neuraminidase inhibitor oseltamivir to usual care speeds up recovery from influenza-like illness by a day compared with usual care alone, with even greater benefits seen in older, sicker patients with comorbidities, according to the ALIC4E study.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
6 days ago
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
11 Jan 2020
Prevention of glucocorticoid-induced osteoporosis (GIOP) and postmenopausal osteoporosis (PMOP) remains inadequate in patients with rheumatoid arthritis (RA), as shown in a study that evaluated the implementation of the 2003 and 2014 French guidelines on the prevention and treatment of GIOP and the 2012 update of the French guidelines for the treatment of PMOP.