Most Read Articles
02 Jul 2018
The use of beta-blockers in patients with heart failure with preserved ejection fraction (HFpEF), especially in those without histories of myocardial infarction, appears to increase the risk of adverse cardiovascular events, according to a recent study.
Stephen Padilla, 6 days ago
Compared with warfarin, apixaban appears to be the safest drug among direct oral anticoagulants (DOACs), with decreased risks of major, intracranial and gastrointestinal bleeding, suggests a study. However, low-dose apixaban and rivaroxaban are associated with increased risks of all-cause mortality compared with warfarin.
24 Jun 2018
Sleep problems and depressive symptoms, and a combination of both, are differentially associated with the future incidence of physical illness, according to a study.
05 Jul 2018
Different measures of fitness and physical activity appear to be inversely associated with the risk of developing cardiovascular disease in the general population, as well as in individuals with elevated genetic risk for these diseases, according to a study.

Hypertension a risk factor for erectile dysfunction?

Jairia Dela Cruz
5 days ago

Hypertensive men appear to be at greater risk of erectile dysfunction (ED) compared with their normotensive counterparts, as shown in a meta-analysis.

“The penis can be considered as a specialized vascular organ and an extension of the vascular system. They are similar to each other both embryologically and physiologically. Therefore, it follows that any disorder that affects the vascular system should also affect the penis and vice versa,” the investigators said.

Pooled data from 18 cross-sectional studies involving 41,943 participants and 10,151 ED patients revealed that hypertension is associated with 84-percent higher odds of ED compared with normal blood pressure (odds ratio [OR], 1.84; 95 percent CI, 1.58–2.14; p<0.000001). [Int J Impot Res 2018;30:141-146]

The association persisted in an analysis controlled for obesity, unfavourable lipid levels, alcohol abuse, physical activity, cigarette smoking, educational level and other lifestyle factors (OR, 1.58; 1.35–1.86; p<0.00001).

There are several potential explanations for why hypertension is a risk factor for ED. According to the investigators, hypertensive patients should also demonstrate the same arteriosclerosis within their penile cavernosal bodies, leading to high vascular resistance and insufficient arterial inflow.

“Another contributing factor may be antihypertensive medicines themselves. Thiazide diuretics and beta blockers are known to worsen ED. The mechanisms have been postulated to be secondary to electrolyte disturbance, volume depletion, inadequate tissue perfusion or damage to smooth muscle cells,” they continued.

Supposing that diuretics are indeed associated with ED, it is said that patients should demonstrate improvement after weeks of discontinuing thiazide. On the other hand, calcium channel blockers and angiotensin converting enzyme inhibitors do not worsen ED compared with placebo.

Despite the presence of limitations, the current meta-analysis points to a possible role for hypertension as an early warning sign for ED, the investigators said. “So it’s a lesson to be learned that hypertension should be more vigorously treated in ageing men with or without ED, in case of ED onset or worsening.”

“On the one hand, for hypertensive patients with ED, it’s a better choice to use the calcium channel blockers, angiotensin converting enzyme inhibitors and angiotensin receptor blockers. On the other hand, for patients with ED who do not have hypertension, it’s necessary to monitor their blood pressure, for early diagnosis and treatment,” they added.

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Most Read Articles
02 Jul 2018
The use of beta-blockers in patients with heart failure with preserved ejection fraction (HFpEF), especially in those without histories of myocardial infarction, appears to increase the risk of adverse cardiovascular events, according to a recent study.
Stephen Padilla, 6 days ago
Compared with warfarin, apixaban appears to be the safest drug among direct oral anticoagulants (DOACs), with decreased risks of major, intracranial and gastrointestinal bleeding, suggests a study. However, low-dose apixaban and rivaroxaban are associated with increased risks of all-cause mortality compared with warfarin.
24 Jun 2018
Sleep problems and depressive symptoms, and a combination of both, are differentially associated with the future incidence of physical illness, according to a study.
05 Jul 2018
Different measures of fitness and physical activity appear to be inversely associated with the risk of developing cardiovascular disease in the general population, as well as in individuals with elevated genetic risk for these diseases, according to a study.