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Hypertension, insulin resistance, IGT prevalent in school children with obesity

27 Aug 2019

There is an unmistakable presence of comorbidities in primary school children who are obese, according to a study. Lifestyle interventions have a greater effect on such comorbidities in primary than in secondary school children, which underscores the necessity of early interventions.

Comorbidities such as insulin resistance (37 percent), impaired glucose tolerance (IGT; 3 percent), dyslipidaemia (48 percent), hypertension (7 percent) and elevated liver transaminase levels (54 percent) were now widespread among primary school children with obesity.

Glomerular hyperfiltration and insulin resistance were more prevalent in secondary school children, whereas IGT was more common in girls.

After intervention, primary vs secondary school children had a greater change in body mass index z score (–0.25±0.32 vs –0.11±0.47), in low-density lipoprotein cholesterol concentrations (–0.30; interquartile range [IQR], –0.70 to 0.10 vs –0.10; IQR, –0.40 to 0.30) and systolic blood pressure z score (–0.32±1.27 vs 0.24±1.3).

Furthermore, boys had a greater change in body mass index z score, but not in comorbidities, than girls (–0.33±0.45 vs –0.05±0.31).

This cross-sectional analysis and lifestyle intervention at the Centre for Overweight Adolescent and Children’s Healthcare assessed the prevalence of comorbidities in school-age children with obesity and compared its prevalence and the effect of a lifestyle intervention between children in primary and secondary school, as well as between boys and girls.

The authors examined comorbidities in 149 primary and 150 secondary school children with (morbid) obesity (162 girls). They also analysed the effect of a 1-year interdisciplinary lifestyle intervention in 82 primary and 75 secondary school children.

“Childhood obesity increases the risk of diseases as diabetes, cardiovascular disease and nonalcoholic fatty liver disease,” the authors said.

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Most Read Articles
6 days ago
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
4 days ago
In patients with atrial fibrillation (AF) and stable coronary artery disease (CAD), rivaroxaban monotherapy is noninferior to combination treatment with an antiplatelet therapy in terms of cutting the risk of cardiovascular events and mortality, according to data from the AFIRE trial.
Elvira Manzano, 5 days ago
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Jairia Dela Cruz, 2 days ago
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