Most Read Articles
Jairia Dela Cruz, 22 Apr 2020
A wristwatch-like device that monitors pulse, breathing and blood oxygen levels of the user allows physicians to provide care remotely both in hospital and nontraditional settings, and may help in the fight against the coronavirus disease 2019 (COVID-19) pandemic.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Stephen Padilla, 28 May 2020
Herd immunity will not work in the novel coronavirus disease (COVID-19), according to an infectious disease expert who addressed over 3,600 primary care physicians (PCP) from Asia Pacific at the inaugural webcast of the MIMS COVID Conversations Series.

Hydroxychloroquine shows greater potency than chloroquine against SARS-CoV-2

08 May 2020

Hydroxychloroquine appears to have more potent in vitro anti-SARS-CoV-2 activity than chloroquine, as shown in a study.

Hydroxychloroquine is said to share the same mechanism of action as chloroquine, although the former has better tolerability, making it the preferred drug to treat malaria and autoimmune conditions. In the current study, researchers tested the hypothesis that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm occurring late-phase in critically ill coronavirus disease 2019 (COVID-19) patients.

The researchers used SARS-CoV-2 infected Vero cells to examine the pharmacological activity of chloroquine and hydroxychloroquine. They built physiologically based pharmacokinetic models (PBPK) for both drugs separately by integrating their in vitro data. These PBPK models facilitated simulation of hydroxychloroquine concentrations in lung fluid under five different dosing regimens to identify the most effective regimen with a good safety profile.

In vitro study revealed that both drugs had good antiviral activity, reducing the viral replication in a concentration-dependent manner. The EC50 values were smaller for hydroxychloroquine than for chloroquine both at 24 hours (6.14 vs 23.90 μM) and at 48 hours (0.72 vs 5.47 μM), indicating superiority of the former in terms of potency.

In the PBPK model, the recommended hydroxychloroquine sulfate regimen for SARS-CoV-2 infection was a loading dose of 400 mg twice daily given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days. This regimen was three times as potent as chloroquine phosphate when given 500 mg twice daily 5 days in advance.

The findings suggest that hydroxychloroquine may be a promising drug for the treatment of SARS-CoV-2 infection, the researchers said.

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Most Read Articles
Jairia Dela Cruz, 22 Apr 2020
A wristwatch-like device that monitors pulse, breathing and blood oxygen levels of the user allows physicians to provide care remotely both in hospital and nontraditional settings, and may help in the fight against the coronavirus disease 2019 (COVID-19) pandemic.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 21 May 2020

Persons suffering from asthma should pay particular attention to SARS-CoV-2 precautionary measures such as social distancing, regular handwashing, and wearing of masks on top of keeping their asthma in control. This is because data collected so far paints a bleaker picture for asthmatics than the normal population should they catch COVID-19.

Stephen Padilla, 28 May 2020
Herd immunity will not work in the novel coronavirus disease (COVID-19), according to an infectious disease expert who addressed over 3,600 primary care physicians (PCP) from Asia Pacific at the inaugural webcast of the MIMS COVID Conversations Series.