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Hydrocortisone as effective as triamcinolone for phimosis

06 Oct 2019
Circumcision has been a controversial issue debated in many countries

Over-the-counter hydrocortisone does not perform worse than triamcinolone for grade 4–5 phimosis, a recent study has found.

Researchers randomly assigned boys aged 3–13 years with phimosis to receive either 0.1% triamcinolone (n=19; mean age, 6.6±2.1 years) or 1% hydrocortisone (n=13; mean age, 5.9±2.5 years). Evaluations were performed at weeks 4, 8 and 12, and treatment success was defined as reaching disease grade 2 after 12 weeks of treatment. Only those with grade 3–4 condition at baseline were eligible for inclusion.

In the hydrocortisone group, 30.8 percent (n=4) were successfully treated by week 4. Over the same time span, 31.6 percent (n=6) of the triamcinolone group had been successfully treated. The corresponding rates in either group increased to 53.8 percent and 52.6 percent by week 8 and 61.5 percent and 68.4 percent by week 12.

Between-group differences in success rates failed to reach statistical significance at any time point (week 4: p=0.99; week 8: p=0.99; week 12: p=0.72). The same was true for adherence.

Similarly, patient age (p=0.16) and a prior history of balanitis had no significant effects on the likelihood of treatment success. Having grade 4 or 5 phimosis at baseline was similarly unrelated to the odds of successful treatment (p=0.27).

No adverse events were reported.

The present study shows that topical corticosteroids remain effective for the treatment for phimosis, and that there appears to be no significant relative superiority of one over others. Treatment duration, on the other hand, seems to be a more important factor, such that prolonged topical exposure may lead to greater chances of success, said researchers.

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Most Read Articles
28 Feb 2018
Maternal influenza and Tdap (tetanus toxoid, reduced diphtheria toxoid, acellular pertussis) vaccinations during pregnancy do not increase the risk for hospitalization or death in infants, a study has shown.
Roshini Claire Anthony, 12 May 2020

Adults who develop peanut allergy in adulthood are less likely to receive a physician diagnosis of their allergy or use epinephrine compared with those with childhood-onset peanut allergy, according to a study from the US.