Most Read Articles
Roshini Claire Anthony, 3 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 4 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Tristan Manalac, 25 May 2020
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.

Hydrochlorothiazide diuretic helps with fluid drainage during breast reconstruction

27 Mar 2020

Hydrochlorothiazide helps lessen the accumulation of interstitial fluid during deep inferior epigastric perforator (DIEP) flap breast reconstruction, a recent study has shown.

Researchers enrolled 60 breast cancer patients who had undergone skin- or nipple-sparing mastectomy and DIEP flap reconstruction. Participants were randomly assigned to receive daily 25-mg hydrochlorothiazide tablets, from the second to the twentieth day after surgery (n=30; mean age, 49.76±6.68 years), or no diuretic (n=30; mean age, 48.67±7.908). Drainage volume and time were some of the study outcomes.

At the donor site, the average total drainage volume removed was 291 mL in the hydrochlorothiazide group, significantly lower than the 436-mL volume in the control group (p=0.003). Similarly, the volume drained at the recipient site was significantly lower in the treatment group (200 vs 286 mL; p=0.032).

In the treatment arm, drainage tubes at the abdominal site was removed after a mean of 7.5 days, while those at the breast were taken off after 6.3 days. The corresponding time intervals to tube removal in the control group were 10.90 and 7.6 days, respectively. The resulting difference in the time needed to remove all drainage tubes was statistically significant (p=0.002).

Moreover, the hydrochlorothiazide tablets significantly reduced the risk of seroma development (16.7 percent vs 43.3 percent; odds ratio, 0.262, 95 percent confidence interval, 0.058–0.858; p=0.024).

“No significant adverse effects were reported in this study; however, additional research in a large-scale multiracial cohort is required before using hydrochlorothiazide as a seroma prevention medication,” the researchers said.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 4 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Tristan Manalac, 25 May 2020
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.