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Human metapneumovirus, rather than RSV, impacts development of hypoxia in asthmatic children

07 Nov 2018

Outbreaks of human metapneumovirus (hMPV) instead of respiratory syncytial virus (RSV) appear to have a greater influence on the development of hypoxic respiratory illness in asthmatic children, a recent study has found.

The number of patients maxed out at age 12–15 and 0–3 months in hMPV and in RSV infection, respectively. There was no difference in the proportion of hypoxic patients (40–50 percent) at any age between hMPV- and RSV-infected children.

Analysis of date from >1-year-old patients with hypoxia showed that those in the hMPV-infection group were older (p=0.036) and more frequently had asthma history (p=0.015) or abnormal chest roentgenogram (p<0.001) than those in the RSV-infection group.

In multivariate analysis, factors associated with hypoxia were as follows: history of asthma in both hMPV (odds ratio [OR], 15.8; p<0.001) and RSV infections (OR, 2.2; p=0.005), higher body temperature in hMPV infection (OR, 2.2; p=0.009), and younger age in RSV infection (OR, 1.4; p=0.004).

In this study, the investigators enrolled a total of 1,217 paediatric inpatients with hMPV (n=114) or RSV (n=1,103) infection in Japan between 2011 and 2014. Bronchial asthma was defined as having >3 episodes of wheezing illness >1 year of age. The positive antigen test for each virus in the nasal specimens determined infection.

The leading causes of acute respiratory illness in children are hMPV and RSV, according to the investigators, adding that “[c]linical burden of each infection on the respiratory distress in asthmatic patients remains unclear.”

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Most Read Articles
09 Jan 2019
Despite comparable efficacies, triamcinolone injections appear to be slightly superior over 5-fluorouracil injections for inducing keloid remission, a recent trial has found.
Jairia Dela Cruz, 6 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 6 days ago
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.