Most Read Articles
6 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
6 days ago
Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.

Hs-cTnI outperforms hs-cTnT in CVD risk assessment in seniors

23 Nov 2020

High-sensitivity cardiac troponin I (hs-cTnI) is a better marker of cardiovascular disease (CVD) risk in elderly adults than hs-cTnT and improves risk stratification in this population, a recent study has found.

Researchers conducted a prospective cohort study on 5,876 elderly adults (mean age, 75.5±5.2 years; 42 percent male) in whom hs-cTnI levels were measured from stored plasma samples. Study outcomes included mortality, surveilled through linkage to a national death registry and semi-annual telephone calls, as well as incident cardiovascular outcomes, such as CVDs, atherosclerotic CVDs, and heart failure.

Over a median follow-up of 6.3 years, a total of 1,053 deaths occurred. Both all-cause and cardiovascular mortalities were higher among elderly adults with elevated hs-cTnI.

In adjusted analyses, an elevated hs-cTnI (≥10 ng/mL for women, ≥12 ng/mL for men) more than doubled the risk of all-cause mortality (hazard ratio [HR], 2.38, 95 percent confidence interval [CI], 1.85–3.06) and almost quadrupled the likelihood of cardiovascular mortality (HR, 3.83, 95 percent CI, 2.33–6.27).

Similarly, elevated hs-cTnI also emerged as a significant risk factor for incident global CVD (HR, 3.41, 95 percent CI, 2.58–4.51), atherosclerotic CVD (HR, 2.02, 95 percent CI, 1.36–2.98), and heart failure (HR, 6.16, 4.24–8.95).

While hs-cTnT also had a comparable effect on the above outcomes, hs-cTnI appeared to be more valuable as a risk stratification factor. Improvements in the model discrimination for global CVD was greater with hs-cTnI (change in C-statistic, 0.0297, 95 percent CI, 0.0144–0.0438; p≤0.001).

The same was true for cardiovascular mortality (change in C-statistic, 0.0108, 95 percent CI, 0.0018–0.0198; p=0.02) and heart failure (change in C-statistic, 0.0465, 95 percent CI, 0.0241–0.0690; p≤0.001), but not for all-cause deaths (p=0.19).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
6 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
6 days ago
Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.