Most Read Articles
Pearl Toh, 6 days ago
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 3 days ago
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
2 days ago
Weight loss medications that have received the Food and Drug Administration (FDA) approval appear to confer only modest positive benefits for cardiometabolic risk profile, according to a study.
3 days ago
The risk of stroke and subsequent mortality is significantly elevated in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), a recent study has shown.

HRQoL stable in glioblastoma patients after escalation 5-fraction stereotactic radiosurgery

27 Jul 2017

Health-related quality of life (HRQoL) remains constant in glioblastoma patients who underwent the prospective dose escalation trial of 5-fraction stereotactic radiosurgery with concurrent and adjuvant temozolomide, a new study shows.

The HRQoL of 30 trial participants (median age 66 years; 50 percent male) was assessed using the QoL questionnaire core-30 (QLQ-C30) and QoL questionnaire-brain cancer specific (QLQ-BN20) modules of the European Organization for Research and Treatment of Cancer, and the M.D. Anderson Symptom Inventory-Brain Tumour (MDAST-BT) questionnaire.

The investigators found a significant reduction of 1.72 points per month from baseline in the communication deficit scale (p=0.008). The false discovery rate was calculated to be 7 percent which indicates that the result was true discovery.

Over a median follow-up of 13.5 months, 26 participants experienced disease progression yielding a 12-month cumulative incidence of 64 percent. Disease progression was significantly associated with communication deficit (p=0.01).

In contrast, there were no significant changes from baseline in terms of global QoL, physical, social and emotional functioning, motor dysfunction, future uncertainty, insomnia and fatigue.

The 12-month cumulative incidence of adverse radiation effects (AREs) was 28 percent (n=8), of which 75 percent (n=6) were symptomatic. AREs were not significantly associated with any of the measures of HRQoL.

Aside from communication deficits, HRQoL was stable in five long-term survivors with a median follow-up of 34.7 months.

All study participants had supratentorial glioblastoma and were treated with increasing doses of hypofractionated stereotactic radiosurgery. Four radiation doses were used: 25, 30, 35 and 40 Gy.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Pearl Toh, 6 days ago
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 3 days ago
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
2 days ago
Weight loss medications that have received the Food and Drug Administration (FDA) approval appear to confer only modest positive benefits for cardiometabolic risk profile, according to a study.
3 days ago
The risk of stroke and subsequent mortality is significantly elevated in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), a recent study has shown.