Most Read Articles
09 Dec 2017
Intravenous (IV) iron is less toxic and more effective compared to oral iron, making it a potential frontline therapy for neonatal iron deficiency anaemia, suggests a recent study.
Shilpa Kolhe, MBBS, MD, MRCOG; Shilpa Deb, MBBS, DGO, MRCOG, 01 Aug 2012

Dysmenorrhoea is a medical condition characterized by severe uterine pain during menstruation manifesting as cyclical lower abdominal or pelvic pain, which may also radiate to the back and thighs. The term dysmenorrhoea is derived from the Greek words ‘dys’ meaning difficult, painful or abnormal, ‘meno’ meaning month, and ‘rrhea’ meaning flow. It is commonly divided into primary dysmenorrhoea, where there is no coexistent pathology, and secondary dysmenorrhoea where there is an identifiable pathological condition known to contribute to painful menstruation. Symptoms of primary dysmenorrhoea begin a few hours before the start of menstruation and are often relieved during the first few days of bleeding. The initial onset of primary dysmenorrhoea is usually shortly after menarche (6–12 months), when ovulatory cycles are established. Secondary dysmenorrhoea can also occur at any time after menarche but is most commonly observed in women in their third and fourth decade of life in association with an existing condition.

02 Dec 2014
Adolescent females often experience menstrual problems, and these are usually related to mood changes. In this study, the association between dysmenorrhea and depressive symptoms, anxiety, and premenstrual syndrome was examined.
26 Feb 2017
Placement of cervical pessary in women with short cervices and singleton pregnancies does not lower the risk of having preterm births, according to the results of a meta-analysis.

HPV genotyping with LBC trumps cytology for cervical screening in SG

23 Aug 2017
Singling out the DNA of HPV as a routine test proven to significantly locate pre-cancerous lesions

Human papillomavirus (HPV)+16/18 genotyping with reflex liquid-based cytology, compared to cytology, detects more cervical intraepithelial neoplasia grade 3 or worse (≥CIN3) and is cost-effective for cervical screening in Singapore, suggests a recent study.

A total of 1,866 women were included in the study; of these, 167 (8.9 percent) had abnormal cytology (≥ASCUS [atypical squamous cells of undetermined significance]) and 171 (9.2 percent) tested positive for high-risk HPV.

There were 23 CIN detected. Of the 10 ≥CIN3 cases, three had negative cytology but positive HPV-16.

Compared to cytology, HPV genotyping detected more ≥CIN3 (odds ratio, 1.43). Furthermore, HPV+16/18 genotyping with reflex LBC was superior to LBC with reflex HPV in terms of cost-effectiveness, both for disease detection rate and cost per case of ≥CIN2 detected.

Researchers retrospectively analysed women who were ≥25 years old and undertook cotesting with LBC and HPV-genotyping for HPV-16, HPV-18 and 12 high-risk HPV types in a single institution. A single cervical smear in ThinPrep PreservCyt solution was separated for tests in independent cytology and molecular pathology laboratories.

A designated gynaecologist reviewed the results based on institutional clinical management protocols. Those who tested positive for HPV-16 and/or HPV-18 (regardless of cytology results), cytology showing low-grade squamous intraepithelial lesions (SIL) or high-grade SIL, or ASCUS with positive 12 high-risk HPV types were referred for colposcopy.

A colposcopist determined cervical biopsy, either directed punch biopsies or excisional biopsy, and a gynaecologic pathologist reviewed the ≥CIN3 diagnosis.

Epidemiological, clinical and financial input data form Singapore were used to analyse the cost-effectiveness of HPV-based screening in terms of disease and financial burden.

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Most Read Articles
09 Dec 2017
Intravenous (IV) iron is less toxic and more effective compared to oral iron, making it a potential frontline therapy for neonatal iron deficiency anaemia, suggests a recent study.
Shilpa Kolhe, MBBS, MD, MRCOG; Shilpa Deb, MBBS, DGO, MRCOG, 01 Aug 2012

Dysmenorrhoea is a medical condition characterized by severe uterine pain during menstruation manifesting as cyclical lower abdominal or pelvic pain, which may also radiate to the back and thighs. The term dysmenorrhoea is derived from the Greek words ‘dys’ meaning difficult, painful or abnormal, ‘meno’ meaning month, and ‘rrhea’ meaning flow. It is commonly divided into primary dysmenorrhoea, where there is no coexistent pathology, and secondary dysmenorrhoea where there is an identifiable pathological condition known to contribute to painful menstruation. Symptoms of primary dysmenorrhoea begin a few hours before the start of menstruation and are often relieved during the first few days of bleeding. The initial onset of primary dysmenorrhoea is usually shortly after menarche (6–12 months), when ovulatory cycles are established. Secondary dysmenorrhoea can also occur at any time after menarche but is most commonly observed in women in their third and fourth decade of life in association with an existing condition.

02 Dec 2014
Adolescent females often experience menstrual problems, and these are usually related to mood changes. In this study, the association between dysmenorrhea and depressive symptoms, anxiety, and premenstrual syndrome was examined.
26 Feb 2017
Placement of cervical pessary in women with short cervices and singleton pregnancies does not lower the risk of having preterm births, according to the results of a meta-analysis.