Most Read Articles
Elaine Soliven, 27 Nov 2019
High levels of trunk fat mass (FM) may be associated with an increased risk of cardiovascular disease (CVD)-related events such as coronary death, nonfatal myocardial infarction, or coronary heart disease in postmenopausal women with normal body mass index (BMI), according to a recent study presented at AHA 2019.
28 Nov 2019
Slideshow: Highlights from the American Heart Association (AHA) Scientific Sessions 2019
28 Oct 2019
The C-reactive protein (CRP)-to-albumin ratio (CAR) appears to be linked to the development of acute kidney injury in patients with ST elevation myocardial infarction (STEMI), a recent study has found.
28 Nov 2019
The addition of evolocumab to high-intensity statin therapy is both well tolerated and effective in significantly reducing low-density lipoprotein cholesterol (LDL-C) levels in patients hospitalized for acute coronary syndromes (ACS), allowing most of them to achieve current recommended target levels, a study has shown.

How do doctors choose to prescribe NOACs vs VKAs for stroke prevention?

19 Jun 2019

The choice between nonvitamin K antagonist oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) for stroke prevention appears to be complex and largely heterogenous across different, countries, a new study has found.

In the 24,137 patients whose records were reviewed, NOACs (n=12,395; 51.4 percent; median age, 72.0 years) had been the medication of choice, though not by a big margin over VKAs (n=11,742; 48.6 percent; median age, 71.0 years). Logistic least absolute shrinkage and selection operator (LASSO) regression was performed to determine predictors of NAOC or VKA use.

Prescription trends of NOACs varied greatly across the 35 countries included in the analysis, ranging from 6.1 percent (of all patients who were given anticoagulants) in Thailand to 87.5 percent in Switzerland. Country of enrolment emerged as the strongest predictor of anticoagulants.

Excluding the country variable, the year of enrolment was found to be the next most influential factor, followed by the setting in which patients were enrolled. Notably, the participants’ clinical and demographic characteristics were consistently the least important factors in anticoagulant choice.

In comparison, LASSO revealed that patients presenting to the emergency care (odds ratio [OR], 1.16, 95 percent CI, 1.04–1.30) or outpatient (OR, 1.15, 1.05–1.25) setting were significantly more likely to be prescribed NOACs than VKAs as a first-line treatment for stroke prevention as opposed to patients who had been admitted into the hospital.

Factors that were predictive of NOAC prescriptions included year of enrolment, increasing age and acute coronary syndrome. On the other hand, having moderate-to-severe kidney disease, heart failure and diabetes were significantly associated with VKA prescriptions.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Elaine Soliven, 27 Nov 2019
High levels of trunk fat mass (FM) may be associated with an increased risk of cardiovascular disease (CVD)-related events such as coronary death, nonfatal myocardial infarction, or coronary heart disease in postmenopausal women with normal body mass index (BMI), according to a recent study presented at AHA 2019.
28 Nov 2019
Slideshow: Highlights from the American Heart Association (AHA) Scientific Sessions 2019
28 Oct 2019
The C-reactive protein (CRP)-to-albumin ratio (CAR) appears to be linked to the development of acute kidney injury in patients with ST elevation myocardial infarction (STEMI), a recent study has found.
28 Nov 2019
The addition of evolocumab to high-intensity statin therapy is both well tolerated and effective in significantly reducing low-density lipoprotein cholesterol (LDL-C) levels in patients hospitalized for acute coronary syndromes (ACS), allowing most of them to achieve current recommended target levels, a study has shown.