Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, Yesterday

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

4 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Audrey Abella, 07 Aug 2018
The use of the investigational first-in-class attachment inhibitor fostemsavir led to improved baseline viral and CD4+ T-cell counts in patients with HIV-1 infection who had limited treatment options and were failing their current antiretroviral regimen, according to the subgroup analysis results of the BRIGHTE* study presented at AIDS 2018.

Home-based exercise improves aerobic power in cirrhosis patients

17 Jan 2018

In patients with cirrhosis, 8 weeks of a home-based exercise training (HET) regimen effectively improves exercise capacity, peak aerobic power (peak VO2) and 6-minute walk distance (6MWD), particularly in those with high adherence, a recent study has shown.

Researchers randomized 40 participants (mean age 57 years; 58 percent male) to receive either 8 weeks of HET, comprised of moderate-to-high‒intensity cycling 3 days/week, or usual care. Peak VO2 showed significant improvement from baseline in the HET group (1.44±0.40 to 1.57±0.56 L/min; p=0.04) but not in the control group (1.87±0.66 to 1.87±0.70 L/min; p=0.98).

The changes in peak VO2 were statistically comparable between the two groups (mean change, 0.15; 95 percent CI, ‒0.03 to 0.32; p=0.095).

In terms of secondary outcomes, there was a statistically significant improvement in aerobic endurance in the 6MWD test in favour the HET group (mean change, 33.7 m; 5.1–62.4; p=0.02). Significant improvements in thigh circumference (p=0.02) and thigh muscle thickness (p=0.05) were also observed in the HET group alone.

Categorizing the HET participants according to adherence produced two groups of almost equal size: those who completed 80 percent of the sessions (adherers; 55 percent; n=11) and those who completed less (nonadherers; 45 percent; n=9).

Subsequent analyses showed that improvements were more pronounced and significant in adherers. Peak VO2 increased from 18.5±4.5 at baseline to 21.4±6.7 mL/kg/min at study end (p=0.01) while the 6MWD improved from 503.6±96.3 to 534.0±102.7 m (p=0.003).

HET did not significantly affect quality of life relative to usual care, and no adverse events were recorded.

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Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, Yesterday

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

4 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Audrey Abella, 07 Aug 2018
The use of the investigational first-in-class attachment inhibitor fostemsavir led to improved baseline viral and CD4+ T-cell counts in patients with HIV-1 infection who had limited treatment options and were failing their current antiretroviral regimen, according to the subgroup analysis results of the BRIGHTE* study presented at AIDS 2018.