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Home-based exercise improves aerobic power in cirrhosis patients

17 Jan 2018

In patients with cirrhosis, 8 weeks of a home-based exercise training (HET) regimen effectively improves exercise capacity, peak aerobic power (peak VO2) and 6-minute walk distance (6MWD), particularly in those with high adherence, a recent study has shown.

Researchers randomized 40 participants (mean age 57 years; 58 percent male) to receive either 8 weeks of HET, comprised of moderate-to-high‒intensity cycling 3 days/week, or usual care. Peak VO2 showed significant improvement from baseline in the HET group (1.44±0.40 to 1.57±0.56 L/min; p=0.04) but not in the control group (1.87±0.66 to 1.87±0.70 L/min; p=0.98).

The changes in peak VO2 were statistically comparable between the two groups (mean change, 0.15; 95 percent CI, ‒0.03 to 0.32; p=0.095).

In terms of secondary outcomes, there was a statistically significant improvement in aerobic endurance in the 6MWD test in favour the HET group (mean change, 33.7 m; 5.1–62.4; p=0.02). Significant improvements in thigh circumference (p=0.02) and thigh muscle thickness (p=0.05) were also observed in the HET group alone.

Categorizing the HET participants according to adherence produced two groups of almost equal size: those who completed 80 percent of the sessions (adherers; 55 percent; n=11) and those who completed less (nonadherers; 45 percent; n=9).

Subsequent analyses showed that improvements were more pronounced and significant in adherers. Peak VO2 increased from 18.5±4.5 at baseline to 21.4±6.7 mL/kg/min at study end (p=0.01) while the 6MWD improved from 503.6±96.3 to 534.0±102.7 m (p=0.003).

HET did not significantly affect quality of life relative to usual care, and no adverse events were recorded.

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Most Read Articles
Tristan Manalac, 12 Aug 2018
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.
Jairia Dela Cruz, 10 Aug 2018
Noninclusion of antibiotics in the management of uncomplicated acute diverticulitis is feasible and fairly safe, with long-term follow-up data from the DIABOLO study showing that such a strategy does not result in increased incidence of complicated or recurrent diverticulitis or sigmoid resections over 2 years.
Tristan Manalac, 11 Aug 2018
Consumption of whole-cricket powder appears to promote the growth of the probiotic gut bacterium Bifidobacterium animalis and reduce plasma concentrations of tumour necrosis factor-α, according to a recent trial.