Most Read Articles
17 May 2018
Patients with Helicobacter pylori (H. pylori) infection have a significantly increased risk of nonalcoholic fatty liver disease (NAFLD), results of a recent meta-analysis have shown.
24 Apr 2017

Helicobacter pylori (H. pylori) infection is associated with conditions such as gastritis, peptic ulcer, gastric cancer, and certain types of lymphoma. A common presenting complaint among all these H. pylori-related illnesses is dyspepsia. Dr Desmond Wai from the Desmond Wai Liver and Gastrointestinal Diseases Centre, Mount Elizabeth Novena Specialist Centre, Singapore, speaks on the important role general practitioners (GPs) play in recognizing, diagnosing, and treating H. pylori.

Home-based exercise improves aerobic power in cirrhosis patients

17 Jan 2018

In patients with cirrhosis, 8 weeks of a home-based exercise training (HET) regimen effectively improves exercise capacity, peak aerobic power (peak VO2) and 6-minute walk distance (6MWD), particularly in those with high adherence, a recent study has shown.

Researchers randomized 40 participants (mean age 57 years; 58 percent male) to receive either 8 weeks of HET, comprised of moderate-to-high‒intensity cycling 3 days/week, or usual care. Peak VO2 showed significant improvement from baseline in the HET group (1.44±0.40 to 1.57±0.56 L/min; p=0.04) but not in the control group (1.87±0.66 to 1.87±0.70 L/min; p=0.98).

The changes in peak VO2 were statistically comparable between the two groups (mean change, 0.15; 95 percent CI, ‒0.03 to 0.32; p=0.095).

In terms of secondary outcomes, there was a statistically significant improvement in aerobic endurance in the 6MWD test in favour the HET group (mean change, 33.7 m; 5.1–62.4; p=0.02). Significant improvements in thigh circumference (p=0.02) and thigh muscle thickness (p=0.05) were also observed in the HET group alone.

Categorizing the HET participants according to adherence produced two groups of almost equal size: those who completed 80 percent of the sessions (adherers; 55 percent; n=11) and those who completed less (nonadherers; 45 percent; n=9).

Subsequent analyses showed that improvements were more pronounced and significant in adherers. Peak VO2 increased from 18.5±4.5 at baseline to 21.4±6.7 mL/kg/min at study end (p=0.01) while the 6MWD improved from 503.6±96.3 to 534.0±102.7 m (p=0.003).

HET did not significantly affect quality of life relative to usual care, and no adverse events were recorded.

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Most Read Articles
17 May 2018
Patients with Helicobacter pylori (H. pylori) infection have a significantly increased risk of nonalcoholic fatty liver disease (NAFLD), results of a recent meta-analysis have shown.
24 Apr 2017

Helicobacter pylori (H. pylori) infection is associated with conditions such as gastritis, peptic ulcer, gastric cancer, and certain types of lymphoma. A common presenting complaint among all these H. pylori-related illnesses is dyspepsia. Dr Desmond Wai from the Desmond Wai Liver and Gastrointestinal Diseases Centre, Mount Elizabeth Novena Specialist Centre, Singapore, speaks on the important role general practitioners (GPs) play in recognizing, diagnosing, and treating H. pylori.