Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.

HKU researchers identify mutation in H7N9 that enhances human infection

Dr. Joseph Delano Fule Robles
27 Mar 2017

Investigators from The University of Hong Kong (HKU) recently identified a mutation in H7N9 virus which causes the virus to possess a higher ability to infect humans while maintaining its ability to circulate effectively in poultry.

Genetic analysis revealed that the NS segment of the H7N9 virus contains a G540A substitution mutation located in the exonic splicing enhancer motif in the mRNA of influenza A viruses. The G540A mutation allows virus replication in mammalian cells while retaining replication ability in avian cells. [Nat Commun 2017, doi:10.1038/ncomms14751]

“This mutation may provide an important biomarker for monitoring transmission of avian influenza viruses in humans and preventing human-to-human transmission of the viruses. The mutation can also serve as a novel target of anti-influenza drug development,” said Professor Honglin Chen of the State Key Laboratory for Emerging Infectious Diseases and Department of Microbiology, HKU.

The outbreak of H7N9 avian influenza was first detected in Eastern China in 2013. As of February 2017, 1,258 H7N9 cases have been confirmed with a 41 percent death rate. [MMWR Morb Mortal Wkly Rep 2017;66:254-255] 

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Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.