Most Read Articles
6 days ago
A recent study has assessed the long-term safety of nine systemic medications for psoriasis, revealing the lowest incidence of adverse events with ustekinumab and secukinumab.
Jairia Dela Cruz, 5 days ago
Following vegan and vegetarian diets, which offer plenty of what is good for health, has been reported to have a downside: an increased risk of depression and anxiety, especially for younger adults.
Tristan Manalac, 18 hours ago
Infants born to mothers with the coronavirus disease 2019 (COVID-19) during the third trimester of pregnancy do not show altered cellular or humoral immunity, nor do they have unbalanced lymphocyte differentiation, according to a recent study.
Pearl Toh, 4 days ago
Taking 600 mg aspirin daily significantly reduces the risk of colon cancer over 10 years in people with Lynch syndrome — which genetically predisposes them to colon cancer, the CAPP*2 study shows.

Product Highlight - Xarelto

25 Jun 2020
The First & Only NOAC Approved for CAD/PAD1*
Xarelto, co-administered with ASA, is indicated for the prevention of atherothrombotic events in adult patients with CAD or symptomatic PAD at high risk of ischaemic events.2

In the COMPASS trial, Xarelto 2.5 mg bid + aspirin vs aspirin alone:
• -24% primary outcome: CV death, stroke or MI (p<0.001)3
• -23% all-cause mortality in CAD patients (p=0.0012)4
• -46% MALE and major amputations in PAD patients (p=0.0037)5
• No significant increase in the risk of most serious bleeding3
• Recommended by the 2019 ESC6 and ESVM7 Guidelines

ASA: acetylsalicylic acid; CAD: coronary artery disease; CV: cardiovascular; ESC: European Society of Cardiology; ESVM: European Society for Vascular Medicine; MALE: major adverse limb events; MI: myocardial infarction; NOAC: non-vitamin K oral anticoagulant; PAD: peripheral artery disease.

*As of Apr 1, 2020

References:
1. U.S. FDA Approves XARELTO® (rivaroxaban) to Reduce the Risk of Major Cardiovascular Events in Patients with Chronic Coronary Artery Disease (CAD) or Peripheral Artery Disease (PAD) [news release]. Titusville, NJ; October 11, 2018: Janssen Pharmaceuticals website. https://www.janssen.com/us-fda-approves-xareltor-rivaroxaban-reduce-risk-major-cardiovascular-events-patients-chronic. Accessed Apr 1, 2020.
2. Xarelto Hong Kong prescribing information.
3. Eikelboom JW, et al. N Engl J Med 2017;377:1319–1330.
4. Connolly SJ, et al. Lancet 2017; doi: 10.1016/S0140–6736(17)32458–3.
5. Anand SS, et al. J Am Coll Cardiol 2019;73:3271–80.
6. Neumann FJ, et al. European Heart Journal (2019) 00, 1-71. doi:10.1093/eurheartj/ehz425.
7. Frank U, et al. Vasa (2019), 48 (Supplement 102).


 

Related MIMS Drugs

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Hong Kong digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
6 days ago
A recent study has assessed the long-term safety of nine systemic medications for psoriasis, revealing the lowest incidence of adverse events with ustekinumab and secukinumab.
Jairia Dela Cruz, 5 days ago
Following vegan and vegetarian diets, which offer plenty of what is good for health, has been reported to have a downside: an increased risk of depression and anxiety, especially for younger adults.
Tristan Manalac, 18 hours ago
Infants born to mothers with the coronavirus disease 2019 (COVID-19) during the third trimester of pregnancy do not show altered cellular or humoral immunity, nor do they have unbalanced lymphocyte differentiation, according to a recent study.
Pearl Toh, 4 days ago
Taking 600 mg aspirin daily significantly reduces the risk of colon cancer over 10 years in people with Lynch syndrome — which genetically predisposes them to colon cancer, the CAPP*2 study shows.